Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

127 questions · 128 findings · 30 reviews · Pregnancy and Childbirth

No studies found 31 · 24.2%GRADE not reported 11 · 8.6%Very low 17 · 13.3%Low 43 · 33.6%Moderate 19 · 14.8%High 7 · 5.5%

DCC with immediate neonatal care after cord clamping vs ECC (subgroup analysis by gestation)

Severe intraventricular haemorrhage · babies born preterm, and their mothers

DCC with immediate neonatal care after cord clamping showed no clear difference in severe intraventricular haemorrhage (IVH grades 3, 4) compared with ECC (subgroup analysis by gestation) (low certainty).

1 finding from 1 review

DCC with immediate neonatal care after cord clamping vs ECC (subgroup analysis by gestation)

Intraventricular haemorrhage · babies born preterm, and their mothers

DCC with immediate neonatal care after cord clamping leads to lower intraventricular haemorrhage (IVH, all grades) compared with ECC (subgroup analysis by gestation) (high certainty).

1 finding from 1 review

DCC with immediate neonatal care after cord clamping vs ECC (subgroup analysis by gestation)

Periventricular leukomalacia · babies born preterm, and their mothers

DCC with immediate neonatal care after cord clamping showed no clear difference in periventricular leukomalacia (PVL) compared with ECC (subgroup analysis by gestation) (low certainty).

1 finding from 1 review

Intervention not reported

Proteinuric pre‐eclampsia · pregnant women considered to be at risk of developing pre‐eclampsia

The intervention leads to lower proteinuric pre‐eclampsia (high certainty).

1 finding from 1 review

Interventionist care vs expectant care

Intraventricular haemorrhage or hypoxic ischaemic encephalopathy · women with severe pre‐eclampsia between 24 and 34 weeks' gestation

Interventionist care probably leads to higher intraventricular haemorrhage or hypoxic ischaemic encephalopathy compared with expectant (delayed delivery) care (moderate certainty).

1 finding from 1 review

Amnioinfusion vs no amnioinfusion

Perinatal death or severe morbidity · pregnant women with confirmed or suspected chorioamnionitis

The review found no eligible studies for this question.

1 finding from 1 review

Vitamin E vs placebo, no placebo or other supplements

Intrauterine growth restriction · pregnant women receiving vitamin E supplementation or control, living in areas where there is either inadequate dietary intake of vitamin…

Any vitamin E supplementation showed no clear difference in intrauterine growth restriction (various definitions) compared with placebo, no placebo or other supplements (high certainty).

1 finding from 1 review

Intervention not reported

Intrauterine growth restriction · All pregnant women receiving either vitamin C supplementation or control either in areas where there is inadequate dietary intake or where…

The intervention showed no clear difference in intrauterine growth restriction (high certainty).

1 finding from 1 review