Cochrane · systematic review · CD014498
Interventions affecting the nitric oxide pathway versus placebo or no therapy for fetal growth restriction in pregnancy
Pels, A, Ganzevoort, W, Kenny, LC, et al. · Cochrane Database of Systematic Reviews · 2023 · Cochrane Library
Pregnancy and ChildbirthAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
12
current version
GRADE rated
12
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 9 · 75%Moderate 3 · 25%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Sildenafil citrate compared to placebo or no therapy for fetal growth restriction
Population: pregnant women with fetal growth restriction
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
All‐cause mortality Sildenafil citrate vs placebo or no therapy | RR 1.01 [0.8, 1.27] | 5 studies · 516 participants | Moderate |
Fetal mortality Sildenafil citrate vs placebo or no therapy | RR 0.82 [0.6, 1.12] | 5 studies · 516 participants | Moderate |
Neonatal mortality Sildenafil citrate vs placebo or no therapy | RR 1.45 [0.9, 2.33] | 5 studies · 397 participants | Moderate |
Tadalafil compared with placebo or no therapy for fetal growth restriction
Population: pregnant women with fetal growth restriction
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
All‐cause mortality Tadalafil vs placebo or no therapy | RR 0.2 [0.02, 1.6] | 1 study · 87 participants | Low |
Fetal mortality Tadalafil vs placebo or no therapy | RR 0.11 [0.01, 1.96] | 1 study · 87 participants | Low |
Neonatal mortality Tadalafil vs placebo or no therapy | RR 0.89 [0.06, 13.7] | 1 study · 83 participants | Low |
Nitroglycerin compared to placebo or no therapy for fetal growth restriction
Population: pregnant women with fetal growth restriction
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
All‐cause mortality Nitroglycerin vs placebo or no therapy | no estimate extracted | 1 study · 23 participants | Low |
Fetal mortality Nitroglycerin vs placebo or no therapy | no estimate extracted | 1 study · 23 participants | Low |
Neonatal mortality Nitroglycerin vs placebo or no therapy | no estimate extracted | 1 study · 23 participants | Low |
Sildenafil citrate compared to nitroglycerin for fetal growth restriction
Population: pregnant women with fetal growth restriction
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
All‐cause mortality Sildenafil citrate vs nitroglycerin | no estimate extracted | 1 study · 23 participants | Low |
Fetal mortality Sildenafil citrate vs nitroglycerin | no estimate extracted | 1 study · 23 participants | Low |
Neonatal mortality Sildenafil citrate vs nitroglycerin | no estimate extracted | 1 study · 23 participants | Low |