Cochrane · systematic review · CD004069
Vitamin E supplementation in pregnancy
Rumbold, A, Ota, E, Hori, H, et al. · Cochrane Database of Systematic Reviews · 2015 · Cochrane Library
Pregnancy and ChildbirthAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
6
current version
GRADE rated
6
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 1 · 16.7%Moderate 2 · 33.3%High 3 · 50%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Any vitamin E supplementation versus placebo, no placebo or other supplements
Population: pregnant women receiving vitamin E supplementation or control, living in areas where there is either inadequate dietary intake of vitamin E or where there is presumed adequate intake.
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Stillbirth Any vitamin E supplementation vs placebo, no placebo or other supplements | RR 1.17 [0.88, 1.56] | 9 studies · 19023 participants | Moderate Downgraded: imprecision |
Preterm birth (less than 37 weeks' gestation) Any vitamin E supplementation vs placebo, no placebo or other supplements | RR 0.98 [0.88, 1.09] | 11 studies · 20565 participants | High |
Clinical pre‐eclampsia (random‐effects model) Any vitamin E supplementation vs placebo, no placebo or other supplements | RR 0.91 [0.79, 1.06] | 14 studies · 20878 participants | Moderate Downgraded: imprecision, inconsistency, publication bias |
Intrauterine growth restriction (various definitions) Any vitamin E supplementation vs placebo, no placebo or other supplements | RR 0.98 [0.91, 1.06] | 11 studies · 20202 participants | High |
Prelabour rupture of fetal membranes ‐ preterm Any vitamin E supplementation vs placebo, no placebo or other supplements | RR 1.27 [0.93, 1.75] | 5 studies · 1999 participants | Low Downgraded: imprecision, inconsistency |
Bleeding episodes (placental abruption) Any vitamin E supplementation vs placebo, no placebo or other supplements | RR 0.64 [0.44, 0.93] | 7 studies · 14922 participants | High |