Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,245 questions · 1,274 findings · 321 reviews

No studies found 247 · 19.4%GRADE not reported 195 · 15.3%Very low 372 · 29.2%Low 282 · 22.1%Moderate 141 · 11.1%High 37 · 2.9%

Lung cancer screening with chest radiography +/‐ sputum cytology vs less intense screening

Lung cancer 5‐year survival ‐ More frequent chest x‐ray screening versus less frequent screening · Patients with lung cancer

Lung cancer screening with chest radiography +/‐ sputum cytology may leads to lower lung cancer 5‐year survival ‐ More frequent chest x‐ray screening… compared with less intense screening (low certainty).

1 finding from 1 review

GnRHa depot vs GnRHa daily injection

Ongoing pregnancy / live birth rate per woman · women undergoing pituitary suppression in assisted reproduction

GnRHa depot showed no clear difference in live birth/ongoing pregnancy rate per woman Delivery of one or more… compared with gnRHa daily injection (low certainty).

1 finding from 1 review

Laser‐assisted in‐situ keratomileusis (LASIK) vs photorefractive keratectomy (PRK)

Lost one or more lines of BCVA · patients with myopia

Laser‐assisted in‐situ keratomileusis (LASIK) showed no clear difference in lost one or more lines of BCVA compared with photorefractive keratectomy (PRK) (low certainty).

1 finding from 1 review

Interleukin‐2 RA induction vs monoclonal antibody induction

Acute rejection Acute rejection grade 3A or more verified by biopsy · heart transplant recipients

Interleukin‐2 RA induction showed no clear difference in acute rejection Acute rejection grade 3A or more verified by biopsy compared with monoclonal antibody induction (low certainty).

1 finding from 1 review

Intervention not reported

Acute rejection Acute rejection grade 3A or more verified by biopsy · heart transplant recipients

The intervention showed no clear difference in acute rejection Acute rejection grade 3A or more verified by biopsy (low certainty).

1 finding from 1 review

Interleukin‐2 RA vs polyclonal antibody induction

Acute rejection Acute rejection grade 3A or more verified by biopsy · heart transplant recipients

Interleukin‐2 RA may leads to higher acute rejection Acute rejection grade 3A or more verified by biopsy compared with polyclonal antibody induction (low certainty).

1 finding from 1 review

Intervention not reported

HIV incidence: CD4 subgroups (350 or more CD4 cells/µL) (observational studies) · Serodiscordant couples

The intervention may leads to lower HIV incidence: CD4 subgroups (350 or more CD4 cells/µL)… (low certainty).

1 finding from 1 review

Intervention not reported

Virologically linked HIV incidence: CD4 subgroups (350 or more CD4 cells/µL) (RCT) · Serodiscordant couples

The intervention leads to lower virologically linked HIV incidence: CD4 subgroups (350 or more CD4… (high certainty).

1 finding from 1 review

Anti‐leukotrienes & ICS vs same‐dose ICS

Number of participants experiencing one or more episode requiring treatment with oral steroids · children with asthma

Anti‐leukotrienes & ICS may leads to lower participants with one or more exacerbations requiring oral… compared with same dose ICS (low certainty).

1 finding from 1 review

Anti‐leukotrienes & ICS vs ICS dose increase

Number of participants experiencing one or more episode requiring treatment with oral steroids · children with asthma

Anti‐leukotrienes & ICS may leads to lower participants with one or more exacerbations requiring oral… compared with higher dose ICS (low certainty).

1 finding from 1 review

Intermittent 'as needed' ICS vs daily ICS

Number of participants experiencing one or more episode requiring treatment with oral steroids · Children and adults with persistent asthma.

Intermittent 'as needed' ICS showed no clear difference in patients with 1 or more exacerbations requiring oral corticosteroids… compared with daily ICS (low certainty).

1 finding from 1 review