Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,271 questions · 1,326 findings · 329 reviews

No studies found 247 · 18.6%GRADE not reported 237 · 17.9%Very low 379 · 28.6%Low 285 · 21.5%Moderate 141 · 10.6%High 37 · 2.8%

Oral paracetamol vs placebo

Patients with one or more adverse events · Patients requiring surgical removal of a lower wisdom tooth or teeth, with baseline moderate to severe pain (surgery under local…

Paracetamol (single oral dose, any dose or formulation; subgroups up… showed no clear difference in patients with one or more adverse events compared with placebo; GRADE not reported.

1 finding from 1 review

Single-visit root canal treatment vs Multiple-visit root canal treatment (two or more visits)

Pain at 12 months or more (long-term postobturation pain) · People aged 10 years or above requiring root canal treatment; permanent teeth with completely formed apex and without internal resorption
1 finding from 1 review

Antibiotics vs placebo

Exacerbations · Adults (aged 40 or over) with COPD presenting with 1 or more exacerbations in the previous year. The 2 larger studies (Albert 2011; Sethi…

Antibiotics probably leads to lower number of people with one or more exacerbations WMD of compared with placebo (moderate certainty).

1 finding from 1 review

More intensive vs less intensive insulin therapy

Transplant or graft survival · pre‐existing and new‐onset diabetes in kidney transplant recipients

It is very uncertain whether more intensive changes transplant or graft survival compared with less intensive insulin therapy (very low certainty).

1 finding from 1 review

More intensive vs less intensive insulin therapy

Delayed graft function · pre‐existing and new‐onset diabetes in kidney transplant recipients

It is very uncertain whether more intensive changes delayed graft function Time frame: 1 to 3 years compared with less intensive insulin therapy (very low certainty).

1 finding from 1 review

More intensive vs less intensive insulin therapy

Death: unknown time frame · pre‐existing and new‐onset diabetes in kidney transplant recipients

It is very uncertain whether more intensive changes death (any cause) Time frame: 1 to 5 years compared with less intensive insulin therapy (very low certainty).

1 finding from 1 review