Question · asked by 1 review
Oral paracetamol vs placebo: Patients with one or more adverse events
- Population
- Patients requiring surgical removal of a lower wisdom tooth or teeth, with baseline moderate to severe pain (surgery under local anaesthesia, intravenous sedation, or general anaesthesia; patients taking concurrent analgesia excluded)
- Intervention
- Oral paracetamol
- Comparison
- placebo
- Outcome
- Patients with one or more adverse events
Paracetamol (single oral dose, any dose or formulation; subgroups up… showed no clear difference in patients with one or more adverse events compared with placebo; GRADE not reported.
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Paracetamol (single oral dose, any dose or formulation; subgroups up to 1000 mg and 1000 mg or more) vs Placebo Patients with one or more adverse events · Patients requiring surgical removal of a lower wisdom tooth or teeth, with baseline moderate to severe pain (surgery… · up to 7 days Paracetamol (single oral dose, any dose or formulation; subgroups up… showed no clear difference in patients with one or more adverse events compared with placebo; GRADE not reported. Paracetamol for pain relief after surgical removal of lower wisdom teeth (2007) · Cochrane All outcomes | RR 1.19 [0.90, 1.57] | 17 studies · 1645 participants | GRADE not reported |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Paracetamol for pain relief after surgical removal of lower wisdom teeth 2007 · Cochrane All outcomes | 2006-08 | Not listed | Not assessed |
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.