Cochrane · systematic review · CD001991
Screening for lung cancer
Manser, R, Lethaby, A, Irving, LB, et al. · Cochrane Database of Systematic Reviews · 2013 · Cochrane Library
Lung CancerAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
11
current version
GRADE rated
11
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 2 · 18.2%Moderate 2 · 18.2%High 7 · 63.6%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Lung cancer screening with chest radiography +/‐ sputum cytology versus less intense screening for lung cancer
Population: Patients with lung cancer
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Lung cancer mortality ‐ More frequent chest x‐ray screening versus less frequent screening Lung cancer screening with chest radiography +/‐ sputum cytology vs less intense screening | RR 1.11 [0.95, 1.31] | 4 studies · 81303 participants | Moderate Downgraded: risk of bias |
Lung cancer mortality ‐ Annual chest x‐ray plus 4‐monthly cytology versus annual x‐ray alone Lung cancer screening with chest radiography +/‐ sputum cytology vs less intense screening | RR 0.88 [0.74, 1.03] | 2 studies · 20427 participants | High |
All‐cause mortality ‐ More frequent chest x‐ray screening versus less frequent screening Lung cancer screening with chest radiography +/‐ sputum cytology vs less intense screening | RR 1.01 [0.94, 1.08] | 4 studies · 170149 participants | Low Downgraded: risk of bias, inconsistency |
All‐cause mortality ‐ Annual chest x‐ray plus 4‐monthly cytology versus annual x‐ray alone Lung cancer screening with chest radiography +/‐ sputum cytology vs less intense screening | RR 1.03 [0.91, 1.15] | 1 study · 10040 participants | High |
Lung cancer 5‐year survival ‐ More frequent chest x‐ray screening versus less frequent screening Lung cancer screening with chest radiography +/‐ sputum cytology vs less intense screening | RR 0.91 [0.84, 0.99] | 4 studies · 1775 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Lung cancer 5‐year survival ‐ Annual chest x‐ray plus 4‐monthly cytology versus annual x‐ray alone Lung cancer screening with chest radiography +/‐ sputum cytology vs less intense screening | RR 0.83 [0.75, 0.92] | 1 study · 837 participants | Moderate Downgraded: risk of bias, imprecision |
Annual chest x‐ray screening versus usual care (no regular screening) for lung cancer
Population: Patients with lung cancer
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Lung cancer mortality at 6 years of Annual chest x‐ray screening vs usual care (no regular screening) | RR 0.91 [0.81, 1.03] | 1 study · 154901 participants | High |
Lung cancer mortality at 13 years of Annual chest x‐ray screening vs usual care (no regular screening) | RR 0.99 [0.91, 1.07] | 1 study · 154901 participants | High |
Deaths from all causes (excluding deaths from PLCO cancers) Annual chest x‐ray screening vs usual care (no regular screening) | RR 0.98 [0.96, 1.01] | 1 study · 154901 participants | High |
Annual low‐dose CT screening versus annual chest x‐ray for lung cancer
Population: Patients with lung cancer
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Lung cancer mortality Annual low‐dose CT screening vs annual chest x‐ray | RR 0.8 [0.7, 0.92] | 1 study · 53454 participants | High |
All‐cause mortality Annual low‐dose CT screening vs annual chest x‐ray | RR 0.94 [0.88, 1] | 1 study · 53454 participants | High |