Cochrane · systematic review · CD002808
Depot versus daily administration of gonadotrophin‐releasing hormone agonist protocols for pituitary down regulation in assisted reproduction cycles
Albuquerque, LET, Tso, LO, Saconato, H, et al. · Cochrane Database of Systematic Reviews · 2013 · Cochrane Library
Gynaecology and FertilityAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
11
current version
GRADE rated
11
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 1 · 9.1%Low 9 · 81.8%Moderate 1 · 9.1%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
GnRHa depot compared to GnRHa daily injection for pituitary down regulation in assisted reproduction cycles
Population: patients with pituitary down regulation in assisted reproduction cycles
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Live birth/ongoing pregnancy rate per woman Delivery of one or more living infants/pregnancy beyond 12 weeks of gestation GnRHa depot vs GnRHa daily injection | OR 0.95 [0.7, 1.31] | 7 studies · 873 participants | Low Downgraded: risk of bias, publication bias |
Clinical pregnancy rate per woman Identified by the presence of a gestational sac on ultrasonography or histopathological confirmation of trophoblast tissue GnRHa depot vs GnRHa daily injection | OR 0.96 [0.75, 1.23] | 11 studies · 1259 participants | Moderate Downgraded: risk of bias |
OHSS incidence rates GnRHa depot vs GnRHa daily injection | OR 0.84 [0.29, 2.42] | 5 studies · 570 participants | Low Downgraded: risk of bias, publication bias |
Miscarriage rates GnRHa depot vs GnRHa daily injection | OR 1.16 [0.7, 1.94] | 9 studies · 512 participants | Low Downgraded: risk of bias, publication bias |
Number of oocytes retrieved GnRHa depot vs GnRHa daily injection | no estimate extracted | 11 studies · 1142 participants | Low Downgraded: risk of bias |
Multiple pregnancy rates GnRHa depot vs GnRHa daily injection | OR 1.1 [0.49, 2.46] | 4 studies · 132 participants | Low Downgraded: risk of bias, publication bias |
Number of gonadotropin (FSH) units employed GnRHa depot vs GnRHa daily injection | no estimate extracted | 11 studies · 1043 participants | Low Downgraded: risk of bias |
Different doses of GnRHa depot compared to GnRHa daily injection for pituitary down regulation in assisted reproduction cycles
Population: patients with pituitary down regulation in assisted reproduction cycles
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Number of gonadotrophin (FSH) units employed ‐ half dose Different doses of GnRHa depot vs GnRHa daily injection | no estimate extracted | 5 studies · 616 participants | Very low Downgraded: risk of bias, inconsistency |
Number of gonadotrophin (FSH) units employed ‐ full dose Different doses of GnRHa depot vs GnRHa daily injection | no estimate extracted | 6 studies · 527 participants | Low Downgraded: risk of bias |
Number of days of gonadotrophin treatment ‐ half dose Different doses of GnRHa depot vs GnRHa daily injection | no estimate extracted | 4 studies · 507 participants | Low Downgraded: risk of bias, inconsistency |
Number of days of gonadotrophin treatment ‐ full dose Different doses of GnRHa depot vs GnRHa daily injection | no estimate extracted | 6 studies · 526 participants | Low Downgraded: risk of bias, inconsistency |