Cochrane · systematic review · CD009153
Antiretroviral therapy for prevention of HIV transmission in HIV‐discordant couples
Anglemyer, A, Rutherford, GW, Horvath, T, et al. · Cochrane Database of Systematic Reviews · 2013 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
11
current version
GRADE rated
11
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 2 · 18.2%Low 5 · 45.5%Moderate 2 · 18.2%High 2 · 18.2%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Show all 3 versionsAntiretroviral Therapy for HIV Prevention in Serodiscordant Couples (Part A)
Population: Serodiscordant couples
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Virologically linked HIV incidence (RCT) | Rate Ratio 0.04 [0, 0.27] | 1 study · 1750 participants | High |
HIV incidence (observational studies) | Rate Ratio 0.58 [0.35, 0.96] | 9 studies · 46204 participants | Moderate |
HIV incidence (observational studies‐‐sensitivity analysis) | Rate Ratio 0.36 [0.17, 0.75] | 7 studies · 46560 participants | Moderate |
HIV incidence: CD4 subgroups (<200 cells/µL) (observational studies) | RR 0.12 [0.02, 0.81] | 5 studies · 26594 participants | Low Downgraded: imprecision |
HIV incidence: CD4 subgroups (200‐350 CD4 cells/µL) (observational studies) | RR 0.66 [0.47, 0.92] | 4 studies · 9595 participants | Very low Downgraded: imprecision |
HIV incidence: CD4 subgroups (350 or more CD4 cells/µL) (observational studies) | RR 0.12 | 3 studies · 13426 participants | Low Downgraded: imprecision |
Virologically linked HIV incidence: CD4 subgroups (350 or more CD4 cells/µL) (RCT) | RR 0.04 [0, 0.27] | 1 study · 1750 participants | High |
Antiretroviral Therapy for HIV Prevention in Serodiscordant Couples (Part B)
Population: Serodiscordant couples
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
HIV incidence: gender subgroup (female cases) | RR 0.39 [0.13, 1.18] | 3 studies · 15608 participants | Low Downgraded: imprecision |
HIV incidence: gender subgroup (male Cases) | RR 0.11 [0.01, 1.62] | 3 studies · 25073 participants | Low Downgraded: imprecision |
HIV incidence: low‐/middle‐income countries | RR 0.53 [0.29, 0.97] | 7 studies · 45029 participants | Low Downgraded: imprecision |
HIV incidence: high income countries | RR 0.77 [0.33, 1.83] | 2 studies · 1061 participants | Very low Downgraded: imprecision |