Cochrane · systematic review · CD009153

Antiretroviral therapy for prevention of HIV transmission in HIV‐discordant couples

Anglemyer, A, Rutherford, GW, Horvath, T, et al. · Cochrane Database of Systematic Reviews · 2013 · Cochrane Library

HIV/AIDS3 versionsAMSTAR 2: not assessed

SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.

Questions

current version

GRADE rated

No studies

Included studies

No studies 0 · 0%Ungraded 0 · 0%Very low 2 · 18.2%Low 5 · 45.5%Moderate 2 · 18.2%High 2 · 18.2%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

Questions and results

Current version only

Antiretroviral Therapy for HIV Prevention in Serodiscordant Couples (Part A)

Population: Serodiscordant couples

CD009153.PUB3 (current) · 7 questions

Outcome	Effect	Evidence	Status / GRADE
Virologically linked HIV incidence (RCT)	Rate Ratio 0.04 [0, 0.27]	1 study · 1750 participants	High
HIV incidence (observational studies)	Rate Ratio 0.58 [0.35, 0.96]	9 studies · 46204 participants	Moderate
HIV incidence (observational studies‐‐sensitivity analysis)	Rate Ratio 0.36 [0.17, 0.75]	7 studies · 46560 participants	Moderate
HIV incidence: CD4 subgroups (<200 cells/µL) (observational studies)	RR 0.12 [0.02, 0.81]	5 studies · 26594 participants	Low Downgraded: imprecision
HIV incidence: CD4 subgroups (200‐350 CD4 cells/µL) (observational studies)	RR 0.66 [0.47, 0.92]	4 studies · 9595 participants	Very low Downgraded: imprecision
HIV incidence: CD4 subgroups (350 or more CD4 cells/µL) (observational studies)	RR 0.12	3 studies · 13426 participants	Low Downgraded: imprecision
Virologically linked HIV incidence: CD4 subgroups (350 or more CD4 cells/µL) (RCT)	RR 0.04 [0, 0.27]	1 study · 1750 participants	High

Antiretroviral Therapy for HIV Prevention in Serodiscordant Couples (Part B)

Population: Serodiscordant couples

CD009153.PUB3 (current) · 4 questions

Outcome	Effect	Evidence	Status / GRADE
HIV incidence: gender subgroup (female cases)	RR 0.39 [0.13, 1.18]	3 studies · 15608 participants	Low Downgraded: imprecision
HIV incidence: gender subgroup (male Cases)	RR 0.11 [0.01, 1.62]	3 studies · 25073 participants	Low Downgraded: imprecision
HIV incidence: low‐/middle‐income countries	RR 0.53 [0.29, 0.97]	7 studies · 45029 participants	Low Downgraded: imprecision
HIV incidence: high income countries	RR 0.77 [0.33, 1.83]	2 studies · 1061 participants	Very low Downgraded: imprecision

Antiretroviral Therapy for HIV Prevention in Serodiscordant Couples (Part A)

Population: Serodiscordant couples

CD009153.PUB2 · 7 questions

Outcome	Effect	Evidence	Status / GRADE
Virologically linked HIV incidence (RCT)	Rate Ratio 0.04 [0, 0.27]	1 study · 1750 participants	High
HIV incidence (observational studies)	Rate Ratio 0.34 [0.13, 0.92]	7 studies · 6792 participants	Moderate
HIV incidence (observational studies‐‐sensitivity analysis)	Rate Ratio 0.17 [0.08, 0.37]	5 studies · 2282 participants	Moderate
HIV incidence: CD4 subgroups (<200 cells/µL) (observational studies)	RR 0.1 [0.07, 0.73]	4 studies · 504 participants	Low Downgraded: imprecision
HIV incidence: CD4 subgroups (200‐350 CD4 cells/µL) (observational studies)	RR 0.33 [0.09, 1.27]	3 studies · 1686 participants	Very low Downgraded: imprecision
HIV incidence: CD4 subgroups (350 or more CD4 cells/µL) (observational studies)	RR 0.02 [0, 2.87]	2 studies · 3431 participants	Low Downgraded: imprecision
Virologically linked HIV incidence: CD4 subgroups (350 or more CD4 cells/µL) (RCT)	RR 0.04 [0, 0.27]	1 study · 1750 participants	High

Antiretroviral Therapy for HIV Prevention in Serodiscordant Couples (Part B)

Population: Serodiscordant couples

CD009153.PUB2 · 4 questions

Outcome	Effect	Evidence	Status / GRADE
HIV incidence: gender subgroup (female cases)	RR 0.15 [0.01, 2.02]	2 studies · 704 participants	Low Downgraded: imprecision
HIV incidence: gender subgroup (male Cases)	RR 0.02 [0, 0.89]	2 studies · 1115 participants	Low Downgraded: imprecision
HIV incidence: low‐/middle‐income countries	RR 0.27 [0.07, 1.13]	5 studies · 5617 participants	Low Downgraded: imprecision
HIV incidence: high income countries	RR 0.77 [0.33, 1.83]	2 studies · 1061 participants	Very low Downgraded: imprecision

Antiretroviral Therapy for HIV Prevention in Serodiscordant Couples (Part A)

Population: patients with HIV Prevention in Serodiscordant Couples (Part A)

CD009153 · 5 questions

Outcome	Effect	Evidence	Status / GRADE
HIV Incidence	Rate Ratio 0.34 [0.13, 0.92]	7 studies · 6792 participants	Moderate
HIV Incidence (Sensitivity)	Rate Ratio 0.17 [0.08, 0.37]	5 studies · 2282 participants	Moderate
HIV Incidence: CD4 Subgroups (<200 cells/µ)	RR 0.1 [0.07, 0.73]	4 studies · 504 participants	Low Downgraded: imprecision
HIV Incidence: CD4 Subgroups (200‐350 CD4 cells/µ)	RR 0.33 [0.09, 1.27]	3 studies · 1686 participants	Very low Downgraded: imprecision
HIV Incidence: CD4 Subgroups (350 or more CD4 cells/µ)	RR 0.02 [0, 2.87]	2 studies · 3431 participants	Low Downgraded: imprecision

Antiretroviral Therapy for HIV Prevention in Serodiscordant Couples (Part B)

Population: patients with HIV Prevention in Serodiscordant Couples (Part B)

CD009153 · 4 questions

Outcome	Effect	Evidence	Status / GRADE
HIV Incidence: Gender Subgroup (Female Cases)	RR 0.15 [0.01, 2.02]	2 studies · 704 participants	Low Downgraded: imprecision
HIV Incidence: Gender Subgroup (Male Cases)	RR 0.02 [0, 0.89]	2 studies · 1115 participants	Low Downgraded: imprecision
HIV Incidence: Low‐/Middle‐Income Countries	RR 0.27 [0.07, 1.13]	5 studies · 5617 participants	Low Downgraded: imprecision
HIV Incidence: High Income Countries	RR 0.77 [0.33, 1.83]	2 studies · 1061 participants	Very low Downgraded: imprecision