Cochrane · systematic review · CD009611
Intermittent versus daily inhaled corticosteroids for persistent asthma in children and adults
Chauhan, BF, Chartrand, C, Ducharme, FM · Cochrane Database of Systematic Reviews · 2013 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
8
current version
GRADE rated
8
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 4 · 50%Moderate 4 · 50%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Show all 2 versionsIntermittent 'as needed' ICS versus daily ICS for persistent asthma in children and adults
Population: Children and adults with persistent asthma.
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Patients with 1 or more exacerbations requiring oral corticosteroids (duration 12 to 52 weeks) Intermittent 'as needed' ICS vs daily ICS | RR 1.07 [0.87, 1.32] | 7 studies · 1204 participants | Low |
Patients with serious adverse health events (duration 12 to 52 weeks) Intermittent 'as needed' ICS vs daily ICS | RR 0.82 [0.33, 2.03] | 6 studies · 1055 participants | Low |
Patients with at least 1 exacerbation requiring emergency department/acute care visit (duration 12 to 52 weeks) Intermittent 'as needed' ICS vs daily ICS | RR 1.08 [0.9, 1.3] | 6 studies · 1055 participants | Low |
Change from baseline AM PEFR (%) (duration 44 to 52 weeks) Intermittent 'as needed' ICS vs daily ICS | no estimate extracted | 3 studies · 350 participants | Moderate |
Proportion of asthma control days over the period (duration 44 to 52 weeks) Intermittent 'as needed' ICS vs daily ICS | no estimate extracted | 3 studies · 330 participants | Moderate |
Change from baseline mean daily use of β2‐agonists (puffs/day) (duration 24 to 44 weeks) Intermittent 'as needed' ICS vs daily ICS | MD 0.12 [0, 0.23] | 3 studies · 442 participants | Moderate |
Change in height (cm) (duration 44 to 52 weeks) Intermittent 'as needed' ICS vs daily ICS | MD 0.41 [0.13, 0.69] | 4 studies · 532 participants | Moderate |
Overall withdrawals (duration 12 to 52 weeks) Intermittent 'as needed' ICS vs daily ICS | OR 1.05 [0.75, 1.46] | 7 studies · 1210 participants | Low |