Mean DMFT (decayed, missing, filled permanent teeth) · Institutionalized orphan children (roughly 3 to 18 years)
Permanent-teeth caries experience (DMF) was marginally higher in institutionalized children but essentially similar to parented children (pooled MD 0.09, not significant; very low certainty).
1 finding from 1 review
Dental caries · Children (<18 years) with vs without dental caries
After removing Zhang 2006, the over-dominant model at BsmI(rs1544410) remained non-significant (OR 0.85); ungraded.
2 findings from 1 review
Dental caries prevalence · Brazilian children/adolescents in permanent dentition (BMI classified by CDC 2000 growth charts)
Normal-weight adolescents in the permanent dentition probably have greater odds of dental caries than obese peers (OR 2.53; moderate certainty).
1 finding from 1 review
Malignant transformation (oral cancer development) · Adults in case-control studies (oral cancer patients vs healthy controls)
Pooling across all missing-teeth measures, the overall association with oral cancer was not statistically significant (OR 1.20, 95% CI 0.97-1.48; high heterogeneity, I2=82.8%); ungraded.
1 finding from 1 review
Dental caries - genome-wide-significant loci · Japanese adults (present-study cohort: 30,859 dental caries cases / 14,666 controls)
The present Japanese GWAS found no genome-wide-significant loci for dental caries (top suggestive rs140784657); ungraded.
1 finding from 1 review
Genome-wide association meta-analysis identifies two novel loci associated with dental caries. 2024 All outcomesLifelong (germline genotype) · Population-based genetic association study (Japanese direct-to-consumer genetic testing cohort) · Present-study GWAS (Japanese)
In the present Japanese GWAS, no loci reached genome-wide significance (P<5E-8) for dental caries; several loci reached the suggestive level (P<1E-5). Top-associated variant rs140784657 (intergenic). All 47 lead…
1 study · 45525 participants
GRADE not reported
Spontaneous space closure · Children and adolescents after extraction of a mandibular permanent first molar (before eruption of the second molar)
In the mandible, mesial inclination of the second molar vs upright was not significantly associated with space closure (OR 0.68; not GRADE-rated).
1 finding from 1 review
Early childhood caries (ECC) · Preschool children (<6 years)
Breastfeeding for <4 vs ≥4 months was not significantly associated with early childhood caries (RR 0.95, 95% CI 0.80-1.13; ungraded).
1 finding from 1 review
Intervention not reported
Cariogenic microbiota counts (Streptococcus mutans, Lactobacillus spp.)
1 finding from 1 review
Intervention not reported
Overall success (composite of clinical and radiographic success)
1 finding from 1 review
Early childhood caries (ECC) · Children with average age ≤3 years
No significant association between cesarean vs vaginal delivery and ECC among children with average age ≤3 years (OR 0.86, 95% CI 0.67-1.10).
1 finding from 1 review
OR 0.86 [0.67, 1.10]
10 studies
GRADE not reported
Caries experience (mean DMFT) · Brazilian children in primary dentition (BMI classified by CDC 2000 growth charts)
Obesity may make little or no difference to caries experience (dmft) in the primary dentition (very low certainty).
1 finding from 1 review
Salivary S. mutans level · Humans with salivary bacteria measured
Salivary F. nucleatum and S. mutans levels were positively associated.
1 finding from 1 review
OR 6.03 [1.55, 23.45]
1 study
GRADE not reported
Positive predictive value · Children and adults with primary or permanent dentition undergoing dental caries assessment
Positive predictive value was reported in 10 studies and varied widely across studies (about 42% to 99%); no pooled estimate and certainty not graded.
1 finding from 1 review
Intervention not reported
Oral cancer (OC)
The intervention led to higher oral cancer (OC); GRADE not reported.
1 finding from 1 review
OR 2.63 [1.92, 3.62]
7 studies
GRADE not reported
Salivary pH · Children and/or adolescents (<18 years) without background systemic disease
Probiotics may make little to no difference to salivary pH versus control (MD -0.12 pH units, 95%CI -0.72 to 0.48; very low certainty).
1 finding from 1 review
Sensitivity · Children and adults with primary or permanent dentition undergoing dental caries assessment
Across 13 studies, the sensitivity of teledentistry (photographic) caries diagnosis versus visual examination ranged from 48% to 98.3%; the review pooled no estimate and did not grade certainty.
1 finding from 1 review
Association between orthodontic treatment duration and ICLs incidence · Patients undergoing fixed orthodontic treatment with fixed (multibracket) appliances, followed for development of new ICLs
ICLs incidence increased with longer orthodontic treatment duration (meta-regression P<.01; ungraded).
1 finding from 1 review
Dental caries in children · Children and/or adolescents (<18 years) without background systemic disease
Probiotics probably make little to no difference to the number of dental caries versus control (MD -0.24 carious pieces, 95%CI -0.72 to 0.23; low certainty).
1 finding from 1 review
Caries arrestment at the individual (patient) level · Children and adults with active dental caries (aged 1-50; mostly preschool/school children with primary dentition)
Pooling two trials, SDF markedly increased individual-level caries arrestment versus placebo (OR 18.10; ungraded subgroup).
1 finding from 1 review
Early childhood caries (ECC) · Preschool children (<6 years)
In cohort studies, breastfeeding for <6 vs ≥6 months was not significantly associated with early childhood caries (RR 0.97, 95% CI 0.88-1.06; ungraded).
2 findings from 1 review