AA+GG (homozygous) genotypes vs GA (heterozygous) genotype: Dental caries
- Population
- Children (<18 years) with vs without dental caries
- Intervention
- AA+GG (homozygous) genotypes
- Comparison
- GA (heterozygous) genotype
- Outcome
- Dental caries
After removing Zhang 2006, the over-dominant model at BsmI(rs1544410) remained non-significant (OR 0.85); ungraded.
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
AA+GG (homozygous) genotypes vs GA (heterozygous) genotype Dental caries · Children (<18 years) with vs without dental caries · Over-dominant model (AA+GG vs GA), Zhang 2006 removed, Children under 18 years; case-control and cross-sectional studies (China, Czech Republic, Turkey, Brazil, India), Sensitivity analysis (Zhang 2006 excluded) After removing Zhang 2006, the over-dominant model at BsmI(rs1544410) remained non-significant (OR 0.85); ungraded. Association of vitamin D receptor gene polymorphisms with caries risk in children: a systematic review and… (2024) All outcomes | OR 0.85 [0.48, 1.49] | 3 studies · 1329 participants | GRADE not reported |
AA+GG (homozygous) genotypes vs GA (heterozygous) genotype Dental caries · Children (<18 years) with vs without dental caries · Over-dominant model (AA+GG vs GA), Children under 18 years; case-control and cross-sectional studies (China, Czech Republic, Turkey, Brazil, India) Over-dominant model (AA+GG vs GA) at BsmI(rs1544410) showed no significant association with caries (OR 0.60; high heterogeneity); ungraded. Association of vitamin D receptor gene polymorphisms with caries risk in children: a systematic review and… (2024) All outcomes | OR 0.60 [0.28, 1.25] | 4 studies · 1741 participants | GRADE not reported |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Association of vitamin D receptor gene polymorphisms with caries risk in children: a systematic review and meta-analysis. 2024 All outcomes | 31 August 2022 | 10 | Not applicable |
Related questions
The same intervention and outcome, asked in another population or against another comparator.
- AA+GG (homozygous) genotypes vs AG (heterozygous) genotype · Children (<18 years) with vs without dental caries · 1 review
Studies behind the findings
The primary studies the full-text reviews tie to this outcome. Reviews with headline outcomes only do not list them here.
- Investigation of Interaction between Vitamin D Receptor Gene Polymorphisms and Environmental Factors in Early Childhood Caries in Chinese… · 2019 · included by 1 of these review
- The relationship between vitamin D receptor gene polymorphism and deciduous tooth decay in Chinese children. · 2017 · included by 1 of these review
- Association between Single Nucleotide Polymorphisms in Vitamin D Receptor Gene Polymorphisms and Permanent Tooth Caries Susceptibility to… · 2017 · included by 1 of these review
- Zhang 2006 · included by 1 of these review
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.