Question · asked by 1 review
Missing teeth / tooth loss vs Fewer or no missing teeth: Malignant transformation (oral cancer development)
- Population
- Adults in case-control studies (oral cancer patients vs healthy controls)
- Intervention
- Missing teeth / tooth loss
- Comparison
- Fewer or no missing teeth
- Outcome
- Malignant transformation (oral cancer development)
Pooling across all missing-teeth measures, the overall association with oral cancer was not statistically significant (OR 1.20, 95% CI 0.97-1.48; high heterogeneity, I2=82.8%); ungraded.
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Missing teeth / tooth loss vs Fewer or no missing teeth Oral cancer (OC) · Adults in case-control studies of oral cancer · Not specified, Case-control studies conducted in Asia (n=6), Europe (n=5), USA (n=2) and other countries (n=3), Overall (all missing-teeth measures pooled) Pooling across all missing-teeth measures, the overall association with oral cancer was not statistically significant (OR 1.20, 95% CI 0.97-1.48; high heterogeneity, I2=82.8%); ungraded. Periodontitis and the risk of oral cancer: a meta-analysis of case-control studies. (2024) All outcomes | OR 1.20 [0.97, 1.48] | 6 studies | GRADE not reported |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Periodontitis and the risk of oral cancer: a meta-analysis of case-control studies. 2024 All outcomes | Up to September 2023 (databases from inception) | 16 | Not applicable |
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.