Silver diamine fluoride (SDF) vs placebo control: Caries arrestment at the individual (patient) level
- Population
- Children and adults with active dental caries (aged 1-50; mostly preschool/school children with primary dentition)
- Intervention
- Silver diamine fluoride (SDF)
- Comparison
- placebo control
- Outcome
- Caries arrestment at the individual (patient) level
Pooling two trials, SDF markedly increased individual-level caries arrestment versus placebo (OR 18.10; ungraded subgroup).
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Silver diamine fluoride (SDF; 38% in most trials, 30% in three) vs Placebo (inactive control) Caries arrestment at the individual (patient) level · Children and adults with active dental caries (aged 1-50; mostly preschool/school children with primary dentition) · 3 weeks to 12 months, Children/adults with dental caries; multiple countries; community/clinic care setting not clearly specified, SDF vs placebo Pooling two trials, SDF markedly increased individual-level caries arrestment versus placebo (OR 18.10; ungraded subgroup). The role of silver diamine fluoride as dental caries preventive and arresting agent: a systematic review and… (2024) All outcomes | OR 18.10 [3.89, 84.15] | 2 studies · 102 participants | GRADE not reported |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| The role of silver diamine fluoride as dental caries preventive and arresting agent: a systematic review and meta-analysis. 2024 All outcomes | Not specified (publication window 2014-2024; references accessed July 2024) | 20 | Critically Low / Critically Low |
Related questions
The same intervention and outcome, asked in another population or against another comparator.
- Silver diamine fluoride (SDF) vs Other methods (pooled: ART/glass ionomer cement, nano-silver fluoride, placebo) · Children and adults with active dental caries (aged 1-50; mostly preschool/school… · 1 review
- Silver diamine fluoride (SDF) vs Nano-silver fluoride (NSF; with or without green tea extract) · Children and adults with active dental caries (aged 1-50; mostly preschool/school… · 1 review
- Silver diamine fluoride (SDF) vs Atraumatic restorative treatment (ART) with glass ionomer cement (GIC) or glass ionomer material · Children and adults with active dental caries (aged 1-50; mostly preschool/school… · 1 review
- Silver diamine fluoride (SDF) vs Placebo, control, and/or other interventions · Children and adults without systemic diseases affecting dental health · 1 review
Studies behind the findings
The primary studies the full-text reviews tie to this outcome. Reviews with headline outcomes only do not list them here.
- Topical Effect of Silver Diamine Fluoride in Arresting Dental Caries in Primary Teeth · 2019 · included by 1 of these review
- Topical silver diamine fluoride for dental caries arrest in preschool children: A randomized controlled trial and microbiological analysis… · 2018 · included by 1 of these review
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.