Search review questions

Maximal mouth opening (interincisal distance) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF) · Less than 3 months

Rotation of the mandibular second permanent molar · Children and adolescents after extraction of a mandibular permanent first molar (before eruption of the second molar) · Until eruption of the permanent second molar (median follow-up 4.0 years), Mandible

Early childhood caries (ECC) prevalence (%, dmft>0) · Children younger than 71 months (under 6 years) · GNI $5000-$9999

Caries presence in primary teeth · For interventions, pregnant women and mothers of infants in the first year of life; for outcomes, children up to 6… · Children assessed at 2-3 yrs

Overall success (composite of clinical and radiographic success) · Mature permanent teeth with irreversible pulpitis and carious pulp exposure (treated with full pulpotomy) · >=12 months

Aesthetics · Children and adults (with or without carious lesions)

Early childhood caries (ECC) · Children aged <6 years · Sample size: ≥300

dmft index score · For interventions, pregnant women, mothers or other caregivers of infants in the first year of life; for outcomes,… · Children assessed at 6 yrs

Streptococcus mutans count (CFU/mL) · Children and/or adolescents (<18 years) without background systemic disease · follow-up: mean 4.4 months, Overall (all presentations pooled)

Bacterial growth inhibition (MIC/MBC) · Streptococcus mutans (in vitro cultures and biofilms)

Dental caries · Children (<18 years) with vs without dental caries · Allelic model (T vs C), Primary dentition

Spontaneous space closure · Children and adolescents after extraction of a mandibular permanent first molar (before eruption of the second molar) · Until eruption of the permanent second molar (median follow-up 4.0 years), Mandible

Pocket closure · Adults (> 18 years) with peri-implant mucositis, receiving active treatment

Dental caries (meta of mixed phenotypes: present-study self-report + GLIDE clinical DMFS + UKB self-report/dentures) · Adults from Japanese and European cohorts (present-study Japanese direct-to-consumer cohort + GLIDE consortium and UK… · Lifelong (germline genotype), Meta-analysis: present study + GLIDE + UKB

Early childhood caries (ECC) · Children aged ≤6 years (early childhood) · Exposure and outcome assessed concurrently (observational); children aged ≤6 years, Study design: cross-sectional

Change in probing pocket depth (PPD) · Adults (> 18 years) with recurrent periodontitis, receiving supportive (maintenance) periodontal care · 6 months (change from baseline)

Patient satisfaction · Adults (> 18 years) with recurrent periodontitis, receiving supportive (maintenance) periodontal care

Severity of joint noise · People with temporomandibular disorders (TMD)

Spontaneous space closure · Children and adolescents (<18 years) after extraction of a permanent first molar before eruption of the permanent… · Until eruption of the permanent second molar (median follow-up 4.0 years), Overall

Dental caries · Children (<18 years) with vs without dental caries · Allelic model (T vs C), Real-time quantitative PCR genotyping

Difficulty in mouth opening (participant-reported proxy) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)

Dental pain or sensitivity · Children and adults (with or without carious lesions)

Fluorosis (percentage prevalence in permanent teeth) · Children exposed to topical fluoride when under 6 years old; fluorosis assessed in permanent teeth at 6 to 18 years · Fluorosis assessed when most permanent teeth of interest had erupted (6 to 18 years)

Serum 25-hydroxyvitamin D level · Preschool children ≤6 years

Dental caries prevalence (DMF/dmf score > 0) · Institutionalized orphan children (roughly 3 to 18 years) · Overall (pooled)

Caries arrest · Children and adults (with or without carious lesions) · Permanent dentition

Gingival bleeding index · Children and/or adolescents (<18 years) without background systemic disease · 1.5 months, Single study (Borrell 2021); not pooled

Frequency of joint noise · People with temporomandibular disorders (TMD)

Salivary TNF-α level (pg/mL) · Children and young adults (3-25 years)

Discomfort · People with temporomandibular disorders (TMD)

Early childhood caries (ECC) · Preschool children ≤6 years, North America · North America

Dental caries (ECC) · Preschool children under 6 years of age · First dental examination before age 6 years, Cohort studies; sensitivity analysis excluding studies 35, 42, and 48

Overall success (composite of clinical and radiographic success) · Permanent teeth with carious pulp exposure · >=12 months

Bacterial adhesion or initial colonization · Streptococcus mutans cultures and biofilms

Dental caries experience (DMFT), continuous · Brazilian children/adolescents in permanent dentition (BMI classified by CDC 2000 growth charts)

Difficulty in swallowing (participant-reported proxy) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)

Self-reported joint pain when chewing · People with temporomandibular disorders (TMD) · Short term (10 weeks), Mixed TMD

Alignment rate · People receiving orthodontic treatment with fixed appliances (upper and/or lower full arch) · 8 to 12 weeks

Bacterial adhesion (inhibition) · Streptococcus mutans (in vitro cultures and biofilms)

High salivary S. mutans (over 10^4 CFU/ml) · Adults · Overall

Wits appraisal · Children and adolescents (aged 16 years or younger) with prominent lower front teeth (Class III malocclusion) · End of treatment

ANB · Children and adolescents (aged 16 years or younger) with prominent lower front teeth (Class III malocclusion) · End of treatment

dmft index score · For interventions, pregnant women and mothers of infants in the first year of life; for outcomes, children up to 6… · Children assessed at 5 yrs

Change in clinical attachment level (CAL) · Adults (> 18 years) with a clinical diagnosis of periodontitis, receiving active (non-surgical anti-infective) treatment · 6 months (change from baseline)

Overall success (composite of clinical and radiographic success) · Mature teeth, full pulpotomy, irreversible pulpitis

Oral health practices · Adults in LMIC urban and slum settings

Alignment rate · People receiving orthodontic treatment with fixed appliances (upper and/or lower full arch) · 8 weeks

Early childhood caries (ECC) · Children aged <6 years · Study design: Cohort

High-level S. mutans (over 10^4 CFU/ml) · Periodontitis patients · Post-treatment, Overall

Fluorosis (percentage prevalence in permanent teeth) · Children exposed to topical fluoride when under 6 years old; fluorosis assessed in permanent teeth at 6 to 18 years · Fluorosis assessed when most permanent teeth of interest had erupted (6 to 18 years)