Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

62 questions · 73 findings · 26 reviews · Anaesthesia

No studies found 5 · 6.8%GRADE not reported 4 · 5.5%Very low 21 · 28.8%Low 28 · 38.4%Moderate 12 · 16.4%High 3 · 4.1%

Intervention not reported

High‐intensity pain with lidocaine pretreatment Pain scales · Adult participants receiving propofol for induction of anaesthesia

The intervention leads to lower high‐intensity pain with lidocaine pretreatment Pain scales (high certainty).

1 finding from 1 review

Inhaled NO vs placebo or conventional therapy

Mortality before hospital discharge · all infants and children with congenital heart disease having postoperative management of pulmonary hypertension

It is very uncertain whether inhaled nitric oxide changes mortality prior to discharge1 compared with placebo or conventional therapy (very low certainty).

1 finding from 1 review

CHRONIC: ACEi or ARB vs placebo

All‐cause mortality · Patients undergoing any type of surgery under general anaesthesia receiving ACEIs or ARBs perioperatively

It is very uncertain whether ACEIs or ARBs changes all‐cause mortality compared with placebo (very low certainty).

1 finding from 1 review

CHRONIC: ACEi or ARB vs placebo

Risk of acute myocardial ischaemia · Patients undergoing any type of surgery under general anaesthesia receiving ACEIs or ARBs perioperatively

It is very uncertain whether ACEIs or ARBs changes risk of acute myocardial ischaemia compared with placebo (very low certainty).

1 finding from 1 review

CHRONIC: ACEi or ARB vs placebo

Rate of perioperative cerebrovascular complications · Patients undergoing any type of surgery under general anaesthesia receiving ACEIs or ARBs perioperatively

It is very uncertain whether ACEIs or ARBs changes rate of perioperative cerebrovascular complications compared with placebo (very low certainty).

1 finding from 1 review