Cochrane · systematic review · CD010726
Nitrates for the prevention of cardiac morbidity and mortality in patients undergoing non‐cardiac surgery
Zhao, N, Xu, J, Singh, B, et al. · Cochrane Database of Systematic Reviews · 2016 · Cochrane Library
AnaesthesiaAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
12
current version
GRADE rated
9
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 3 · 25%Very low 9 · 75%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Nitroglycerin versus no treatment for prevention of cardiac morbidity and mortality in participants undergoing non‐cardiac surgery (nitroglycerin vs no treatment)
Population: patients (15 years of age and older) undergoing non‐cardiac surgery under any type of anaesthesia
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
All‐cause mortality in 30 days post operation Nitroglycerin vs no treatment | RR 0.33 [0.01, 7.87] | 1 study · 60 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Acute myocardial infarction Nitroglycerin vs no treatment | RR 0.25 [0.03, 2.2] | 2 studies · 105 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Angina pectoris Nitroglycerin vs no treatment | RR 0.43 [0.12, 1.57] | 2 studies · 105 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Cardiac ischaemia indicated by ECG Nitroglycerin vs no treatment | RR 0.73 [0.42, 1.26] | 4 studies · 197 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Side effect (hypotension) Nitroglycerin vs no treatment | no estimate extracted | 0 studies · 0 participants | Ungraded |
Side effect (headache) Nitroglycerin vs no treatment | RR 3.67 [0.14, 96.14] | 2 studies · 6629 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Nitroglycerin versus placebo for prevention of cardiac morbidity and mortality in patients undergoing non‐cardiac surgery (nitroglycerin vs placebo)
Population: patients (15 years of age and older) undergoing non‐cardiac surgery under any type of anaesthesia
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
All‐cause mortality in 30 days post operation Nitroglycerin vs placebo | RR 2.81 [0.12, 63.83] | 2 studies · 89 participants | Very low Downgraded: risk of bias, imprecision |
Acute myocardial infarction Nitroglycerin vs placebo | RR 4.69 [0.24, 89.88] | 1 study · 29 participants | Very low Downgraded: risk of bias, imprecision |
Angina pectoris Nitroglycerin vs placebo | no estimate extracted | 0 studies · 0 participants | Ungraded |
Cardiac ischaemia indicated by ECG Nitroglycerin vs placebo | no estimate extracted | 2 studies · 56 participants | Ungraded |
Side effect (hypotension) Nitroglycerin vs placebo | RR 1.46 [0.56, 3.83] | 6 studies · 296 participants | Very low Downgraded: risk of bias, imprecision |
Side effect (headache) Nitroglycerin vs placebo | RR 1.55 [0.75, 3.2] | 10 studies · 607 participants | Very low Downgraded: risk of bias, imprecision |