Cochrane · systematic review · CD009210
Perioperative angiotensin‐converting enzyme inhibitors or angiotensin II type 1 receptor blockers for preventing mortality and morbidity in adults
Zou, Z, Yuan, HB, Yang, B, et al. · Cochrane Database of Systematic Reviews · 2016 · Cochrane Library
AnaesthesiaAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 7 · 100%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
ACEIs or ARBs compared to placebo for preventing surgery‐related mortality and morbidity in adults
Population: Patients undergoing any type of surgery under general anaesthesia receiving ACEIs or ARBs perioperatively
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
All‐cause mortality ACEIs or ARBs vs placebo | RR 1.61 [0.44, 5.85] | 3 studies · 419 participants | Very low Downgraded: risk of bias, imprecision |
Risk of acute myocardial ischaemia ACEIs or ARBs vs placebo | RR 0.55 [0.14, 2.26] | 2 studies · 345 participants | Very low Downgraded: risk of bias, imprecision |
Congestive heart failure ACEIs or ARBs vs placebo | no estimate extracted | 2 studies · 34 participants | Very low Downgraded: risk of bias, imprecision |
Hypotension ACEIs or ARBs vs placebo | RR 1.95 [0.86, 4.41] | 1 study · 298 participants | Very low Downgraded: risk of bias, imprecision |
Rate of perioperative cerebrovascular complications ACEIs or ARBs vs placebo | RR 0.48 [0.18, 1.28] | 3 studies · 459 participants | Very low Downgraded: risk of bias, imprecision |
Length of hospital stay ACEIs or ARBs vs placebo | no estimate extracted | 2 studies · 372 participants | Very low Downgraded: risk of bias, imprecision |
Treatment related adverse events ACEIs or ARBs vs placebo | no estimate extracted | 2 studies · 385 participants | Very low Downgraded: risk of bias, imprecision |