Cochrane · systematic review · CD005055
Inhaled nitric oxide for the postoperative management of pulmonary hypertension in infants and children with congenital heart disease
Bizzarro, M, Gross, I, Barbosa, FT · Cochrane Database of Systematic Reviews · 2014 · Cochrane Library
AnaesthesiaAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
6
current version
GRADE rated
5
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 1 · 16.7%Very low 5 · 83.3%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Inhaled nitric oxide compared to placebo or conventional therapy for all infants and children with congenital heart disease having postoperative management of pulmonary hypertension
Population: all infants and children with congenital heart disease having postoperative management of pulmonary hypertension
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Long‐term mortality Inhaled nitric oxide vs placebo or conventional therapy | no estimate extracted | 0 studies · 0 participants | Ungraded |
Mortality prior to discharge1 Inhaled nitric oxide vs placebo or conventional therapy | OR 1.67 [0.38, 7.3] | 2 studies · 162 participants | Very low Downgraded: imprecision, inconsistency |
Difference in MPAP change score (SE) ‐ Conventional Management4 Inhaled nitric oxide vs placebo or conventional therapy | no estimate extracted | 2 studies · 4 participants | Very low |
Difference in MPAP change score (SE) ‐ Placebo4 Inhaled nitric oxide vs placebo or conventional therapy | no estimate extracted | 1 study · 2 participants | Very low Downgraded: risk of bias, inconsistency |
Difference in MAP change score (SE) ‐ Conventional Mangement4 Inhaled nitric oxide vs placebo or conventional therapy | no estimate extracted | 2 studies · 4 participants | Very low Downgraded: imprecision |
Difference in MAP change score (SE) ‐ Placebo4 Inhaled nitric oxide vs placebo or conventional therapy | no estimate extracted | 1 study · 2 participants | Very low Downgraded: risk of bias, inconsistency |