Search review questions

Difficulty in speech (participant-reported proxy) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)

Lactobacillus spp. mean levels/counts · Children and adolescents aged 0 to 18 years with nonsyndromic cleft lip and palate

Dental caries experience (DMFT), continuous · Brazilian children/adolescents in permanent dentition (BMI classified by CDC 2000 growth charts)

Dental caries · Children (<18 years) with vs without dental caries · Dominant model (TT+TC vs CC), Real-time quantitative PCR genotyping

Early childhood caries (ECC) prevalence (%, dmft>0) · Children younger than 71 months (under 6 years) · Region: Africa

Overall success (composite of clinical and radiographic success) · Full pulpotomy, irreversible pulpitis

Fluorosis (percentage prevalence in permanent teeth) · Children exposed to topical fluoride when under 6 years old; fluorosis assessed in permanent teeth at 6 to 18 years · Fluorosis assessed when most permanent teeth of interest had erupted (6 to 18 years)

dmft index score · For interventions, pregnant women, mothers or other caregivers of infants in the first year of life; for outcomes,…

Mean number of missing teeth in OC cases vs controls · Adults in case-control studies (oral cancer patients vs healthy controls) · Not specified, Missing teeth (mean count)

Burning sensation (VAS 0-100) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF) · More than 6 months

Decayed, missing, filled surfaces (DMFS) · Percentage of sites with CAL >=3 mm (tertiles); single study (Robert 2019); adjusted

Serum vitamin D (25(OH)D): ECC vs caries-free · Cross-sectional studies (Fig 3)

Early childhood caries (ECC) · Children aged ≤6 years (early childhood) · Exposure and outcome assessed concurrently (observational); children aged ≤6 years, Region: Asia

Pain · People receiving orthodontic treatment with fixed appliances (upper and/or lower full arch)

Lactobacillus count (CFU/mL) · Children and/or adolescents (<18 years) without background systemic disease · follow-up: mean 5.2 months, Overall (all presentations pooled)

Dental caries · Children · Study region: Australia

Swelling at 72 hours · Adults with a symptomatic necrotic tooth or localised acute apical abscess (no signs of spreading infection or… · 72 hours

Early childhood caries (ECC) · Preschool children ≤6 years

Enamel demineralization / mineral loss · Human enamel specimens under cariogenic challenge (in situ / ex vivo)

Maximal mouth opening (interincisal distance) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF) · 3 to 6 months

Spontaneous space closure · Children and adolescents with maxillary permanent first molar extraction · Follow-up to complete eruption of the permanent second molar, Maxilla

Dental caries / early childhood caries (ECC) · Children (approx. 4-18 years) · Sample size: >900

Joint pain at rest · People with temporomandibular disorders (TMD) · Short term (6 weeks), Disc displacement without reduction (DDwoR)

Ion release · Human teeth with early enamel lesions surrounding orthodontic brackets · 14 days to 6 months

Spontaneous space closure · Children and adolescents after extraction of a mandibular permanent first molar (before eruption of the second molar) · Until eruption of the permanent second molar (median follow-up 4.0 years), Mandible

Dental caries prevalence (any DMFT), dichotomous · Brazilian children/adolescents in permanent dentition (BMI classified by WHO 2006 Z-score)

dmft index score · For interventions, pregnant and lactating women; for outcomes, children up to 6 years of age · Children assessed at 5-6 yrs

Overall success (composite of clinical and radiographic success) · Permanent teeth with carious pulp exposure · >=12 months

ANB · Children and adolescents (aged 16 years or younger) with prominent lower front teeth (Class III malocclusion) · End of treatment

Frequency of joint noise · People with temporomandibular disorders (TMD)

Outcome NR · Adults (> 18 years) with peri-implantitis, receiving supportive treatment

Perceived need for surgery in adulthood · Children and adolescents (aged 16 years or younger) with prominent lower front teeth (Class III malocclusion)

Spontaneous space closure · Children and adolescents after extraction of a mandibular permanent first molar (before eruption of the second molar) · Until eruption of the permanent second molar (median follow-up 4.0 years), Mandible

Early childhood caries (ECC) prevalence (%, dmft>0) · Children younger than 71 months (under 6 years) · Region: Asia-Oceania

Early childhood caries experience (mean dmft) · Children younger than 71 months (under 6 years) · GNI $5000-$9999

Pattern of dental service utilisation and barriers · Adult residents of slums and non-slum urban settings of LMICs

Overall success (composite of clinical and radiographic success) · Permanent teeth with carious pulp exposure · >=12 months, Hemostasis >=10 min

Analgesic use · Adults with symptomatic apical periodontitis (no signs of spreading infection or systemic involvement) · 7 days

Child plaque (any plaque visible on any teeth) · For interventions, pregnant women, mothers or other caregivers of infants in the first year of life; for outcomes,…

White spot lesion incidence · Patients undergoing fixed orthodontic treatment · 2 and 4 months after treatment start

Maximal mouth opening (interincisal distance) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF) · More than 6 months

Primary caries prevention · Children and adults (with or without carious lesions)

Maximal mouth opening (interincisal distance) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF) · Less than 3 months

Primary caries prevention · Children and adults (with or without carious lesions) · 36 months, Permanent dentition (root)

Periodontal disease - SNP-based heritability · Japanese adults (present-study cohort) · Lifelong (germline genotype), LDSC heritability (present study)

Recurrence rate · People with temporomandibular disorders (TMD)

Biofilm morphological changes · Streptococcus mutans (in vitro cultures and biofilms)

Dental caries in children · Children (approx. 4-18 years) · Non-linear dose-response (restricted cubic splines)

Dental caries · Children (<18 years) with vs without dental caries · Recessive model (GG vs GA+AA), Zhang 2006 removed, Sensitivity analysis (Zhang 2006 excluded)

Mother gingival health (mild or moderate bone loss) · For interventions, pregnant women, mothers or other caregivers of infants in the first year of life; for outcomes,…