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What do systematic reviews say?

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Evidence found and GRADE certainty

958 questions · 991 findings · 123 reviews · Headline outcomes only

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No studies found 177 · 17.9%GRADE not reported 25 · 2.5%Very low 230 · 23.2%Low 321 · 32.4%Moderate 185 · 18.7%High 53 · 5.3%

Intervention not reported

Unscheduled use of intravenous fluid · adults and children with acute watery diarrhoea

It is very uncertain whether the intervention changes unscheduled use of intravenous fluid (very low certainty).

1 finding from 1 review

Intervention not reported

Unscheduled use of intravenous fluid · adults and children with acute watery diarrhoea

The intervention may leads to lower unscheduled use of intravenous fluid (low certainty).

1 finding from 1 review

Intervention not reported

Unscheduled use of intravenous fluid in those with mixed pathogen · adults and children with acute watery diarrhoea

The intervention may leads to lower unscheduled use of intravenous fluid in those with mixed pathogen (low certainty).

1 finding from 1 review

Interventions to reduce blood loss during myomectomy for fibroids vs placebo or no treatment

Intravenous injection of tranexamic acid · women with uterine fibroids

Interventions to reduce blood loss during myomectomy for fibroids showed no clear difference in intravenous injection of tranexamic acid compared with placebo or no treatment (low certainty).

1 finding from 1 review

ORS ≤ 270 mOsm/L (glucose‐based) vs ORS ≥ 310 mOsm/L (glucose‐based)

Need for unscheduled intravenous infusion · patients with cholera

ORS ≤ 270 mOsm/L (glucose‐based) showed no clear difference in need for unscheduled intravenous infusion compared with ORS ≥ 310 mOsm/L (glucose‐based) (moderate certainty).

1 finding from 1 review

Oral ondansetron (weight based) vs placebo

Rate of intravenous rehydration during ED stay · patients with vomiting related to acute gastroenteritis with mild to moderate dehydration

Oral ondansetron (weight based) probably leads to lower rate of intravenous rehydration during ED stay compared with placebo (moderate certainty).

1 finding from 1 review

Oral ondansetron (weight based) vs placebo

Rate of intravenous rehydration up to 72 hrs following discharge from ED (best ‐ worst scenario) · patients with vomiting related to acute gastroenteritis with mild to moderate dehydration

Oral ondansetron (weight based) may leads to lower rate of intravenous rehydration up to 72 hrs following discharge… compared with placebo (low certainty).

1 finding from 1 review

Oral ondansetron (weight based) vs placebo

Rate of intravenous rehydration up to 72 hrs following discharge from ED (worst ‐ best scenario) · patients with vomiting related to acute gastroenteritis with mild to moderate dehydration

Oral ondansetron (weight based) may leads to lower rate of intravenous rehydration up to 72 hrs following discharge… compared with placebo (low certainty).

1 finding from 1 review

Buffered vs non‐buffered crystalloid intravenous fluid

Mortality (in‐hospital death and 30‐day mortality) · adults receiving intravenous fluids whilst undergoing any form of surgery

Buffered showed no clear difference in mortality (in‐hospital death and 30‐day mortality) compared with non‐buffered crystalloid intravenous fluid (low certainty).

1 finding from 1 review

Buffered vs non‐buffered crystalloid intravenous fluid

Organ system failure ‐ renal insufficiency requiring support · adults receiving intravenous fluids whilst undergoing any form of surgery

Buffered showed no clear difference in organ system failure ‐ renal insufficiency requiring support compared with non‐buffered crystalloid intravenous fluid (low certainty).

1 finding from 1 review