Cochrane · systematic review · CD006519
Polymer‐based oral rehydration solution for treating acute watery diarrhoea
Gregorio, GV, Gonzales, MLM, Dans, LF, et al. · Cochrane Database of Systematic Reviews · 2016 · Cochrane Library
Infectious DiseasesAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
14
current version
GRADE rated
14
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 6 · 42.9%Low 8 · 57.1%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
'Summary of findings' table 1
Population: adults and children with acute watery diarrhoea
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Total stool output during first 24 hours | no estimate extracted | 1 study · 99 participants | Low Downgraded: risk of bias, imprecision, indirectness |
Duration of diarrhoea | no estimate extracted | 5 studies · 364 participants | Low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Unscheduled use of intravenous fluid | RR 0.66 [0.43, 1.02] | 4 studies · 376 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Vomiting | RR 0.56 [0.24, 1.34] | 1 study · 63 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Hyponatraemia | RR 0.88 [0.43, 1.82] | 3 studies · 145 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
'Summary of findings' table 2
Population: adults and children with acute watery diarrhoea
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Total stool output during first 24 hours | no estimate extracted | 16 studies · 1483 participants | Low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Duration of diarrhoea | no estimate extracted | 16 studies · 1187 participants | Low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Unscheduled use of intravenous fluid | RR 0.75 [0.57, 0.98] | 19 studies · 1877 participants | Low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Unscheduled use of intravenous fluid in those with mixed pathogen | RR 0.63 [0.49, 0.96] | 11 studies · 928 participants | Low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Unscheduled use of intravenous fluid in those with Cholera | RR 0.94 [0.66, 1.34] | 7 studies · 535 participants | Low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Vomiting | RR 0.91 [0.72, 1.14] | 10 studies · 584 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Hyponatraemia | RR 1.82 [0.52, 6.44] | 4 studies · 385 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Hypokalaemia | RR 1.29 [0.74, 2.25] | 2 studies · 260 participants | Low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Development of persistent diarrhoea | RR 1.28 [0.68, 2.41] | 2 studies · 885 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness |