Cochrane · systematic review · CD008382
Very early discharge versus early discharge versus non‐early discharge in children with cancer and febrile neutropenia
Loeffen, EAH, te Poele, EM, Tissing, WJE, et al. · Cochrane Database of Systematic Reviews · 2016 · Cochrane Library
Childhood CancerAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
15
current version
GRADE rated
12
No studies
3
Included studies
NR
No studies 3 · 20%Ungraded 0 · 0%Very low 0 · 0%Low 12 · 80%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Early discharge versus non‐early discharge for children with cancer and febrile neutropenia at low risk for invasive bacterial infection
Population: children with cancer
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Treatment failure; rehospitalization or adjustment of antimicrobial treatment, or both in number of episodes Early discharge vs non‐early discharge | RR 0.91 [0.24, 3.5] | NR | Low Downgraded: risk of bias, imprecision |
Treatment failure; death Early discharge vs non‐early discharge | no estimate extracted | NR | Low Downgraded: risk of bias, imprecision |
Costs in USD Early discharge vs non‐early discharge | no estimate extracted | NR | Low Downgraded: risk of bias, imprecision |
Duration of total antimicrobial treatment in days Early discharge vs non‐early discharge | no estimate extracted | NR | Low Downgraded: risk of bias, imprecision |
Duration of intravenous antimicrobial treatment in days Early discharge vs non‐early discharge | no estimate extracted | NR | Low Downgraded: risk of bias, imprecision |
Duration of oral antimicrobial treatment in days Early discharge vs non‐early discharge | no estimate extracted | NR | Low Downgraded: risk of bias, imprecision |
Quality of life Early discharge vs non‐early discharge | no estimate extracted | NR | No studies |
Very early discharge versus early discharge for children with cancer and febrile neutropenia at low risk for invasive bacterial infection
Population: children with cancer
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Treatment failure; rehospitalization or adjustment of antimicrobial treatment (or both) in number of episodes Very early discharge vs early discharge | RR 0.54 [0.15, 1.89] | NR | Low Downgraded: risk of bias, imprecision |
Treatment failure; rehospitalization or adjustment of antimicrobial treatment (or both), only first episode in number of participants Very early discharge vs early discharge | RR 0.32 [0.07, 1.4] | NR | Low Downgraded: risk of bias, imprecision |
Treatment failure; death Very early discharge vs early discharge | no estimate extracted | NR | Low Downgraded: risk of bias, imprecision |
Costs Very early discharge vs early discharge | no estimate extracted | NR | No studies |
Duration of total antimicrobial treatment Very early discharge vs early discharge | no estimate extracted | NR | Low Downgraded: risk of bias, imprecision |
Duration of intravenous antimicrobial treatment Very early discharge vs early discharge | no estimate extracted | NR | Low Downgraded: risk of bias, imprecision |
Duration of oral antimicrobial treatment Very early discharge vs early discharge | no estimate extracted | NR | Low Downgraded: risk of bias, imprecision |
Quality of life Very early discharge vs early discharge | no estimate extracted | NR | No studies |