Cochrane · systematic review · CD005506
Antiemetics for reducing vomiting related to acute gastroenteritis in children and adolescents
Fedorowicz, Z, Jagannath, VA, Carter, B · Cochrane Database of Systematic Reviews · 2011 · Cochrane Library
GutAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
10
current version
GRADE rated
8
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 2 · 20%Very low 0 · 0%Low 5 · 50%Moderate 3 · 30%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Oral ondansetron (weight based) compared to placebo for vomiting related to acute gastroenteritis in children
Population: patients with vomiting related to acute gastroenteritis with mild to moderate dehydration
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Rate of admission during ED stay Oral ondansetron (weight based) vs placebo | RR 0.4 [0.19, 0.83] | 3 studies · 465 participants | Moderate Downgraded: risk of bias |
Rate of admission 72 hrs Oral ondansetron (weight based) vs placebo | RR 0.6 [0.34, 1.04] | 3 studies · 461 participants | Low Downgraded: risk of bias, inconsistency |
Rate of admission in 72 hrs Oral ondansetron (weight based) vs placebo | RR 0.73 [0.43, 1.22] | 3 studies · 461 participants | Low Downgraded: risk of bias, inconsistency |
Time to cessation of vomiting Oral ondansetron (weight based) vs placebo | no estimate extracted | 0 studies · 0 participants | Ungraded |
Rate of intravenous rehydration during ED stay Oral ondansetron (weight based) vs placebo | RR 0.41 [0.29, 0.59] | 3 studies · 465 participants | Moderate Downgraded: risk of bias |
Rate of intravenous rehydration up to 72 hrs following discharge from ED (best ‐ worst scenario) Oral ondansetron (weight based) vs placebo | RR 0.52 [0.1, 0.38] | 3 studies · 461 participants | Low Downgraded: risk of bias, inconsistency |
Rate of intravenous rehydration up to 72 hrs following discharge from ED (worst ‐ best scenario) Oral ondansetron (weight based) vs placebo | RR 0.57 [0.42, 0.76] | 3 studies · 461 participants | Low Downgraded: risk of bias, inconsistency |
Proportion of patients with cessation of vomiting Oral ondansetron (weight based) vs placebo | RR 1.33 [1.19, 1.49] | 3 studies · 465 participants | Moderate Downgraded: risk of bias |
Revisit rate Oral ondansetron (weight based) vs placebo | RR 1.09 [0.66, 1.79] | 3 studies · 460 participants | Low Downgraded: risk of bias, inconsistency |
Adverse events Oral ondansetron (weight based) vs placebo | no estimate extracted | 3 studies · 465 participants | Ungraded |