Cochrane · systematic review · CD013860
Prophylactic antiemetics for adults receiving intravenous opioids in the acute care setting
Gottlieb, M, Carlson, JN, Peksa, GD · Cochrane Database of Systematic Reviews · 2022 · Cochrane Library
Pain, Palliative and Supportive CareAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
6
current version
GRADE rated
5
No studies
1
Included studies
NR
No studies 1 · 16.7%Ungraded 0 · 0%Very low 0 · 0%Low 5 · 83.3%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Prophylactic dopamine antagonist antiemetic medications versus placebo in adults receiving intravenous opioids
Population: adults receiving intravenous opioids
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Vomiting (≥1 episode) Prophylactic dopamine antagonist antiemetic medications vs placebo | RR 1.18 [0.26, 5.32] | 3 studies · 527 participants | Low Downgraded: risk of bias, imprecision |
Nausea (≥1 episode) Prophylactic dopamine antagonist antiemetic medications vs placebo | RR 0.55 [0.15, 2.03] | 2 studies · 336 participants | Low Downgraded: risk of bias, imprecision |
Adverse events Prophylactic dopamine antagonist antiemetic medications vs placebo | RR 2.34 [0.47, 11.61] | 3 studies · 527 participants | Low Downgraded: risk of bias, imprecision |
Number of vomiting episodes Prophylactic dopamine antagonist antiemetic medications vs placebo | no estimate extracted | NR | No studies |
Nausea severity (postintervention)Scale from: 0 to 10 Prophylactic dopamine antagonist antiemetic medications vs placebo | no estimate extracted | 1 study · 191 participants | Low Downgraded: risk of bias, imprecision |
Rescue medication Prophylactic dopamine antagonist antiemetic medications vs placebo | RR 1.86 [0.17, 20.16] | 3 studies · 527 participants | Low Downgraded: risk of bias, imprecision |