Cochrane · systematic review · CD003754
Oral rehydration salt solution for treating cholera: ≤ 270 mOsm/L solutions vs ≥ 310 mOsm/L solutions
Musekiwa, A, Volmink, J · Cochrane Database of Systematic Reviews · 2011 · Cochrane Library
Infectious DiseasesAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
14
current version
GRADE rated
8
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 6 · 42.9%Very low 0 · 0%Low 4 · 28.6%Moderate 4 · 28.6%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
ORS ≤ 270 mOsm/L (glucose‐based) compared to ORS ≥ 310 mOsm/L (glucose‐based) for treating cholera
Population: patients with cholera
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Death ORS ≤ 270 mOsm/L (glucose‐based) vs ORS ≥ 310 mOsm/L (glucose‐based) | no estimate extracted | 2 studies · 121 participants | Ungraded |
Need for unscheduled intravenous infusion ORS ≤ 270 mOsm/L (glucose‐based) vs ORS ≥ 310 mOsm/L (glucose‐based) | RR 0.86 [0.66, 1.12] | 5 studies · 616 participants | Moderate Downgraded: imprecision |
Symptomatic hyponatraemia ORS ≤ 270 mOsm/L (glucose‐based) vs ORS ≥ 310 mOsm/L (glucose‐based) | no estimate extracted | 5 studies · 620 participants | Ungraded |
Biochemical hyponatraemia (serum sodium < 130 mmol/L) ORS ≤ 270 mOsm/L (glucose‐based) vs ORS ≥ 310 mOsm/L (glucose‐based) | RR 1.67 [1.09, 2.57] | 4 studies · 465 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency |
Severe biochemical hyponatraemia (serum sodium < 125 mmol/L) ORS ≤ 270 mOsm/L (glucose‐based) vs ORS ≥ 310 mOsm/L (glucose‐based) | RR 1.58 [0.62, 4.04] | 4 studies · 465 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Duration of diarrhoea (in hours) ORS ≤ 270 mOsm/L (glucose‐based) vs ORS ≥ 310 mOsm/L (glucose‐based) | no estimate extracted | 6 studies · 683 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency |
Stool output in first 24 hours after admission or randomization ORS ≤ 270 mOsm/L (glucose‐based) vs ORS ≥ 310 mOsm/L (glucose‐based) | no estimate extracted | 4 studies · 581 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency |
ORS ≤ 270 mOsm/L (rice‐based) compared to ORS ≥ 310 mOsm/L (glucose‐based) for treating cholera
Population: patients with cholera
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Death ORS ≤ 270 mOsm/L (rice‐based) vs ORS ≥ 310 mOsm/L (glucose‐based) | no estimate extracted | 0 studies · 0 participants | Ungraded |
Need for unscheduled intravenous infusion ORS ≤ 270 mOsm/L (rice‐based) vs ORS ≥ 310 mOsm/L (glucose‐based) | no estimate extracted | 0 studies · 0 participants | Ungraded |
Symptomatic hyponatraemia ORS ≤ 270 mOsm/L (rice‐based) vs ORS ≥ 310 mOsm/L (glucose‐based) | no estimate extracted | 1 study · 39 participants | Ungraded |
Severe biochemical hyponatraemia(serum sodium < 125 mmol/L) ORS ≤ 270 mOsm/L (rice‐based) vs ORS ≥ 310 mOsm/L (glucose‐based) | RR 0.35 [0.02, 8.1] | 2 studies · 102 participants | Low Downgraded: imprecision |
Biochemical hyponatraemia(serum sodium < 130 mmol/L) ORS ≤ 270 mOsm/L (rice‐based) vs ORS ≥ 310 mOsm/L (glucose‐based) | RR 0.66 [0.26, 1.69] | 2 studies · 102 participants | Low Downgraded: imprecision |
Duration of diarrhoea(in hours) ORS ≤ 270 mOsm/L (rice‐based) vs ORS ≥ 310 mOsm/L (glucose‐based) | no estimate extracted | 2 studies · 102 participants | Low Downgraded: imprecision, inconsistency |
Stool output in first 24 hours after admission or randomization ORS ≤ 270 mOsm/L (rice‐based) vs ORS ≥ 310 mOsm/L (glucose‐based) | no estimate extracted | 0 studies · 0 participants | Ungraded |