Search review questions

Dental caries (proportion of patients with caries) · Children and adolescents aged 0-18 years with non-syndromic cleft lip and palate (CLP)

Periodontopathogenic microbiota composition · Narrative: Campylobacter/Fusobacterium/F. nucleatum/Prevotella intermedia-nigrescens/Parvimonas micra/Porphyromonas gingivalis in CLP

Secondary prevention of caries · Children and adults (with or without carious lesions)

Lactobacillus spp. salivary/plaque counts (cariogenic microbiota) · Children and adolescents aged 0-18 years with non-syndromic cleft lip and palate (CLP)

Overall success (composite of clinical and radiographic success) · Mature teeth, irreversible pulpitis

Change in probing pocket depth (PPD) · Adults (> 18 years) with a clinical diagnosis of periodontitis, receiving active (non-surgical anti-infective) treatment · 3 months (change from baseline)

Dental caries (prevalence) · Adults · Adjusted OR

Fluoride ion release · Human enamel specimens around orthodontic brackets (in vitro) · up to 6 months, Overall

Dental caries · Children (<18 years) with vs without dental caries · Dominant model (TT+TC vs CC), Caucasian ethnicity

Bacterial growth inhibition (MIC/MBC) · Streptococcus mutans (in vitro cultures and biofilms)

Dental caries (prevalence) · Children (<18 years) with intellectual and developmental disabilities (IDD) in India · Overall

Dental caries prevalence · Children aged 2 to 8 years · Maternal pregnancy to child age 2 to 8 years, Children of mothers with low prenatal vitamin D

Fluorosis (percentage prevalence in permanent teeth) · Children exposed to topical fluoride when under 6 years old; fluorosis assessed in permanent teeth at 6 to 18 years · Fluorosis assessed when most permanent teeth of interest had erupted (6 to 18 years)

Early childhood caries (ECC) · Children aged <6 years · Study design: Cross-sectional

dmfs index score (decayed, missing, filled primary surfaces; range 0-80) · For interventions, pregnant women, mothers or other caregivers of infants in the first year of life; for outcomes,… · Children assessed at 1-3 yrs

ANB · Children and adolescents (aged 16 years or younger) with prominent lower front teeth (Class III malocclusion) · End of treatment

Periodontal disease (prevalence) · Children (<18 years) with intellectual and developmental disabilities (IDD) in India

Early childhood caries (ECC) · Children aged ≤6 years (early childhood) · Exposure and outcome assessed concurrently (observational); children aged ≤6 years, Time period: before 2017

Bacterial cell death · Streptococcus mutans cultures and biofilms

ANB · Children and adolescents (aged 16 years or younger) with prominent lower front teeth (Class III malocclusion) · End of treatment

Muscle pain when chewing · People with temporomandibular disorders (TMD)

Serum vitamin D (25(OH)D): ECC vs caries-free · Case-control studies (Fig 3)

White spot lesion area · Patients undergoing fixed orthodontic treatment · During orthodontic treatment

Aesthetics · Children and adults (with or without carious lesions) · 12 months, Children

Dental caries / early childhood caries (ECC) · Children (approx. 4-18 years) · Study design: cross-sectional

dmfs index score · For interventions, pregnant women, mothers or other caregivers of infants in the first year of life; for outcomes,… · Children assessed at 3 yrs

Prenatal vitamin D deficiency prevalence · Pregnant mothers · Pregnancy, Overall

ANB · Children and adolescents (aged 16 years or younger) with prominent lower front teeth (Class III malocclusion) · End of treatment

Dental pain or sensitivity · Children and adults (with or without carious lesions)

Early childhood caries experience (mean dmft) · Children younger than 71 months (under 6 years) · Gini index: low inequality

Overjet · Children and adolescents (aged 16 years or younger) with prominent lower front teeth (Class III malocclusion) · End of treatment (9 to 15 months)

Mother self-reported oral health behaviours · For interventions, pregnant women, mothers or other caregivers of infants in the first year of life; for outcomes,…

Pit-and-fissure caries progression (ICDAS), CO2 laser vs fluoride varnish alone · Rechmann 2013 (single RCT, n=20, 12-month follow-up)

Caries arrestment at the tooth level · Children and adults with active dental caries (aged 1-50; mostly preschool/school children with primary dentition) · 6 to 12 months, SDF vs NAF

Enamel remineralization extent · Human enamel specimens around orthodontic brackets (in vitro) · pH cycling / biofilm challenge 14 to 28 days, Overall

Dental caries in children · Infants and children (aged about 2 to 8 years) whose mothers' vitamin D status was assessed during pregnancy · Maternal 25(OH)D measured at gestational weeks 6 to 38, Gestational-age subgroup: weeks 6 to 38

Overall success (composite of clinical and radiographic success) · Permanent teeth with carious pulp exposure · >=12 months, Hemostasis <=6 min

Wits appraisal · Children and adolescents (aged 16 years or younger) with prominent lower front teeth (Class III malocclusion) · End of treatment

Fluorosis (percentage prevalence in permanent teeth) · Children exposed to topical fluoride when under 6 years old; fluorosis assessed in permanent teeth at 6 to 18 years · Fluorosis assessed when most permanent teeth of interest had erupted (6 to 18 years)

Child dental attendance · For interventions, pregnant women, mothers or other caregivers of infants in the first year of life; for outcomes,… · Birth to 6 yrs

Secondary prevention of caries · Children and adults (with or without carious lesions)

Swelling at 24 hours · Adults with symptomatic apical periodontitis (no signs of spreading infection or systemic involvement) · 24 hours

Early childhood caries (ECC) · Children aged ≤6 years (early childhood) · Exposure and outcome assessed concurrently (observational); children aged ≤6 years, Sample collection: dental plaque

Muscle pain at rest · People with temporomandibular disorders (TMD)

Percussion pain at 24 hours · Adults with a symptomatic necrotic tooth or localised acute apical abscess (no signs of spreading infection or… · 24 hours

Caries presence in primary teeth · For interventions, pregnant women, mothers or other caregivers of infants in the first year of life; for outcomes,… · Children assessed at 3-5 yrs

Early childhood caries experience (mean dmft) · Children younger than 71 months (under 6 years) · Region: Middle East

Maximal mouth opening (interincisal distance) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF) · Less than 3 months

Early childhood caries (ECC) · Children aged <6 years · Study location: Asia

Enamel remineralization / anti-demineralization extent · Human enamel specimens around orthodontic brackets (in vitro) · pH cycling 14 days to 6 months (majority 14 days), Overall