Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

382 questions · 384 findings · 98 reviews

No studies found 54 · 14.1%GRADE not reported 37 · 9.6%Very low 116 · 30.2%Low 99 · 25.8%Moderate 60 · 15.6%High 18 · 4.7%

Combinations of antipsychotic drugs vs single antipsychotic drugs

Adverse events: Serious event or requiring discontinuation · schizophrenia or related disorders

It is very uncertain whether combinations of antipsychotic drugs changes adverse events: Serious event or requiring discontinuation compared with single antipsychotic drugs (very low certainty).

1 finding from 1 review

Intervention not reported

Discontinuation of treatment due to side effects ( · people with or at risk of cardiovascular disease

The intervention probably leads to higher discontinuation of treatment due to side effects ( (moderate certainty).

1 finding from 1 review

Alemtuzumab 24 mg vs interferon beta‐1a

Number of participants with adverse events leading to study discontinuation · patients with relapsing‐remitting multiple sclerosis

It is very uncertain whether alemtuzumab 24 mg changes number of participants experiencing treatment discontinuation caused… compared with interferon beta 1a (very low certainty).

1 finding from 1 review

Alemtuzumab 12 mg vs interferon beta‐1a

Number of participants with adverse events leading to study discontinuation · patients with relapsing‐remitting multiple sclerosis

Alemtuzumab 12 mg may leads to lower number of participants experiencing treatment discontinuation caused… compared with interferon beta 1a (low certainty).

1 finding from 1 review

Intravesically administered BCG combined with IFN‐α vs intravesically administered BCG alone

Discontinuation of therapy due to adverse events ‐ not measured · patients with non‐muscle invasive bladder cancer

The review found no eligible studies for this question.

1 finding from 1 review

Intravesically administered BCG alternating with IFN‐α vs intravesically administered BCG alone

Discontinuation of medication due to adverse events · patients with non‐muscle invasive bladder cancer

Intravesically administered BCG alternating with IFN‐α showed no clear difference in discontinuation of therapy due to adverse events compared with intravesically administered BCG alone (low certainty).

1 finding from 1 review

Are disease‐modifying drugs for a first attack suggestive of multiple sclerosis (MS) effective and safe vs placebo?

Discontinuation of medication due to adverse events

It is very uncertain whether are disease‐modifying drugs for a first attack suggestive of… changes withdrawls or drug discontinuation due to adverse events during 24… compared with placebo? (very low certainty).

1 finding from 1 review

Statins vs placebo

Discontinuation of medication due to adverse events · older people with normal cognitiona

Statins showed no clear difference in adverse events leading to discontinuation of therapy compared with placebo (high certainty).

1 finding from 1 review

Intervention not reported

Discontinuation of therapy due to adverse effects · patients in primary prevention of cardiovascular disease events

It is very uncertain whether the intervention changes discontinuation of therapy due to adverse effects (very low certainty).

1 finding from 1 review

Intervention not reported

Adverse events a. Serious adverse events b. Discontinuation of trial because of adverse events · obese children and adolescents

The intervention showed no clear difference in adverse events a. Serious adverse events b. Discontinuation of trial… (low certainty).

1 finding from 1 review

Rituximab (2 x 1000 mg) plus methotrexate vs methotrexate

Discontinuation of medication due to adverse events · patients with rheumatoid arthritis

Rituximab (2 x 1000 mg) plus methotrexate showed no clear difference in discontinuations due to adverse events Analysis 6.3 compared with methotrexate monotherapy (moderate certainty).

1 finding from 1 review

CBT (plus taper) vs taper

Successful discontinuation of BZDs‐ post treatment Objective and subjective · patients with BZD harmful use, abuse or dependence

CBT (plus taper) probably leads to higher successful discontinuation of BZDs‐ post treatment Objective and… compared with taper (moderate certainty).

1 finding from 1 review