Cochrane · systematic review · CD009005
Antipsychotic combinations for schizophrenia
Ortiz‐Orendain, J, Castiello‐de Obeso, S, Colunga‐Lozano, LE, et al. · Cochrane Database of Systematic Reviews · 2017 · Cochrane Library
SchizophreniaAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
4
No studies
1
Included studies
NR
No studies 1 · 14.3%Ungraded 2 · 28.6%Very low 3 · 42.9%Low 1 · 14.3%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Combinations of antipsychotic drugs compared to single antipsychotic drugs for schizophrenia
Population: schizophrenia or related disorders
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Clinical response: No clinically important response ‐ as defined by each of the studies Combinations of antipsychotic drugs vs single antipsychotic drugs | RR 0.73 [0.64, 0.83] | 29 studies · 2398 participants | Very low Downgraded: risk of bias |
Relapse ‐ as defined by each of the studies Combinations of antipsychotic drugs vs single antipsychotic drugs | no estimate extracted | 3 studies · 512 participants | Ungraded |
Leaving the study early Combinations of antipsychotic drugs vs single antipsychotic drugs | RR 0.9 [0.76, 1.07] | 43 studies · 3137 participants | Low Downgraded: risk of bias, imprecision, inconsistency, indirectness, publication bias |
Service utilisation: Hospital admission Combinations of antipsychotic drugs vs single antipsychotic drugs | RR 0.96 [0.36, 2.55] | 3 studies · 202 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness, publication bias |
Service utilisation: Change in hospital status ‐ not reported Combinations of antipsychotic drugs vs single antipsychotic drugs | no estimate extracted | NR | No studies |
Adverse events: Serious event or requiring discontinuation Combinations of antipsychotic drugs vs single antipsychotic drugs | RR 1.05 [0.65, 1.69] | 30 studies · 2398 participants | Very low Downgraded: risk of bias |
Quality of life Combinations of antipsychotic drugs vs single antipsychotic drugs | no estimate extracted | 4 studies · 398 participants | Ungraded |