Cochrane · systematic review · CD012436
Drug interventions for the treatment of obesity in children and adolescents
Axon, E, Atkinson, G, Richter, B, et al. · Cochrane Database of Systematic Reviews · 2016 · Cochrane Library
Metabolic and Endocrine DisordersAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
6
current version
GRADE rated
5
No studies
1
Included studies
NR
No studies 1 · 16.7%Ungraded 0 · 0%Very low 0 · 0%Low 4 · 66.7%Moderate 1 · 16.7%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Drug interventions for the treatment of obesity in children and adolescents
Population: obese children and adolescents
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
a. BMI (kg/m2) | no estimate extracted | 16 studies · 1884 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Adverse events a. Serious adverse events b. Discontinuation of trial because of adverse events | RR 1.43 [0.63, 3.25] | 5 studies · 1347 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Health‐related quality of life 3 questionnaires (1 trial) and SF‐36 (1 trial) | no estimate extracted | 2 studies · 86 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
All‐cause mortality | no estimate extracted | 20 studies · 2176 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency |
Morbidity | no estimate extracted | 1 study · 533 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Socioeconomic effects | no estimate extracted | NR | No studies |