Statins vs placebo: Discontinuation of medication due to adverse events
- Population
- older people with normal cognitiona
- Intervention
- Statins
- Comparison
- placebo
- Outcome
- Discontinuation of medication due to adverse events
Statins showed no clear difference in adverse events leading to discontinuation of therapy compared with placebo (high certainty).
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Statins vs placebo Adverse events leading to discontinuation of therapy · older people with normal cognitiona Statins showed no clear difference in adverse events leading to discontinuation of therapy compared with placebo (high certainty). Statins for the prevention of dementia (2016) · Cochrane Headline outcomes only | OR 0.94 [0.83, 1.05] | 2 studies · 26340 participants | High |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Statins for the prevention of dementia 2016 · Cochrane Headline outcomes only | Not reported | Not extracted | Not assessed |
Related questions
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How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.