Cochrane · systematic review · CD003160
Statins for the prevention of dementia
McGuinness, B, Craig, D, Bullock, R, et al. · Cochrane Database of Systematic Reviews · 2016 · Cochrane Library
Dementia and Cognitive ImprovementAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 1 · 14.3%High 6 · 85.7%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Statins compared with placebo for prevention of dementia
Population: older people with normal cognitiona
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Incidence of dementia Range of scale yes/no Statins vs placebo | OR 1 [0.61, 1.65] | 1 study · 20536 participants | Moderate Downgraded: imprecision |
Mini Mental State Examination Score Score out of 30 (higher score better) Measures global cognitive function Statins vs placebo | MD 0.06 | 1 study · 5804 participants | High |
Stroop Colour Word Test Total number of seconds required to complete the third Stroop card containing 40 items Measures attention Statins vs placebo | MD 0.8 | 1 study · 5804 participants | High |
Picture‐Word Learning Test 15 Picture Learning Test Measures immediate and delayed recall Statins vs placebo | MD 0.02 | 1 study · 5804 participants | High |
Letter Digit Coding Test Total number of correct entries completed in 60 seconds Measures processing speed Statins vs placebo | no estimate extracted | 1 study · 5804 participants | High |
Mean Modified Telephone Interview for Cognitive Status Score Score out of 39 Statins vs placebo | MD 0.02 | 1 study · 20536 participants | High |
Adverse events leading to discontinuation of therapy Statins vs placebo | OR 0.94 [0.83, 1.05] | 2 studies · 26340 participants | High |