Cochrane · systematic review · CD009753
Fibrates for primary prevention of cardiovascular disease events
Jakob, T, Nordmann, AJ, Schandelmaier, S, et al. · Cochrane Database of Systematic Reviews · 2016 · Cochrane Library
HeartAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
5
current version
GRADE rated
5
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 1 · 20%Low 2 · 40%Moderate 2 · 40%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Summary of findings table
Population: patients in primary prevention of cardiovascular disease events
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Combined CVD death, non‐fatal MI, or non‐fatal stroke | RR 0.84 [0.74, 0.96] | 6 studies · 16135 participants | Moderate Downgraded: risk of bias |
Combined coronary heart disease death or non‐fatal MI | RR 0.79 [0.68, 0.92] | 6 studies · 16135 participants | Moderate Downgraded: risk of bias |
Overall mortality | RR 1.01 [0.81, 1.26] | 5 studies · 8471 participants | Low Downgraded: risk of bias, imprecision, publication bias |
Non‐CVD mortality | RR 1.01 [0.76, 1.35] | 5 studies · 8471 participants | Low Downgraded: risk of bias, imprecision, publication bias |
Discontinuation of therapy due to adverse effects | RR 1.38 [0.71, 2.68] | 3 studies · 4805 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |