Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

82 questions · 83 findings · 60 reviews

No studies found 4 · 4.8%GRADE not reported 9 · 10.8%Very low 25 · 30.1%Low 26 · 31.3%Moderate 12 · 14.5%High 7 · 8.4%

Probiotics vs placebo

Withdrawals due to adverse events · children with chronic constipation without a physical explanation

Probiotic showed no clear difference in withdrawals due to adverse events compared with placebo (low certainty).

1 finding from 1 review

Belimumab 10 mg/kg vs placebo

Withdrawals due to adverse events · people with active systemic lupus erythematosus (but not active nephritis or active central nervous system involvement)

Belimumab 10 mg/kg showed no clear difference in withdrawals due to adverse events compared with placebo (moderate certainty).

1 finding from 1 review

All doses of cerivastatin vs placebo

Withdrawals due to adverse events · participants with normal or abnormal lipid profiles

It is very uncertain whether all doses of cerivastatin changes withdrawals due to adverse events compared with placebo (very low certainty).

1 finding from 1 review

Adalimumab vs placebo

Withdrawals due to adverse events · Participants with Crohn's disease in remission

Adalimumab probably leads to lower withdrawals due to adverse events compared with placebo (moderate certainty).

1 finding from 1 review

Mesalamine vs placebo

Withdrawals due to adverse events · Patients with collagenous colitis

Mesalamine showed no clear difference in withdrawals due to adverse events compared with placebo (low certainty).

1 finding from 1 review

Budesonide vs placebo

Withdrawals due to adverse events · Patients with collagenous colitis

It is very uncertain whether budesonide changes withdrawals due to adverse events compared with placebo (very low certainty).

1 finding from 1 review

Boswellia serrata vs placebo

Withdrawals due to adverse events · Patients with collagenous colitis

Boswellia serrata extract showed no clear difference in withdrawals due to adverse events compared with placebo (low certainty).

1 finding from 1 review