Antidepressants vs placebo: Withdrawals due to adverse events
- Population
- children (4 to 18 years) with functional abdominal pain disorders
- Intervention
- Antidepressants
- Comparison
- placebo
- Outcome
- Withdrawals due to adverse events
Antidepressant showed no clear difference in withdrawals due to adverse events compared with placebo (low certainty).
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Antidepressant vs placebo Withdrawals due to adverse events · Children and adolescents with functional abdominal pain disorder Antidepressant showed no clear difference in withdrawals due to adverse events compared with placebo (low certainty). Antidepressants for functional abdominal pain disorders in children and adolescents (2021) · Cochrane Headline outcomes only | RR 3.17 [0.65, 15.33] | 3 studies · 238 participants | Low |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Antidepressants for functional abdominal pain disorders in children and adolescents 2021 · Cochrane Headline outcomes only | Not reported | Not extracted | Not assessed |
Related questions
The same intervention and outcome, asked in another population or against another comparator.
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How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.