Cochrane · systematic review · CD010668
Belimumab for systemic lupus erythematosus
Singh, JA, Shah, NP, Mudano, AS · Cochrane Database of Systematic Reviews · 2021 · Cochrane Library
MusculoskeletalAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 2 · 28.6%Moderate 3 · 42.9%High 2 · 28.6%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Belimumab 10 mg/kg compared to placebo for systemic lupus erythematosus
Population: people with active systemic lupus erythematosus (but not active nephritis or active central nervous system involvement)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Reduction of at least 4 points in SELENA‐SLEDAI at 52 weeks SELENA‐SLEDAI score, a validated marker of SLE disease activity (range 0 to 105; higher score = worse disease activity) Belimumab 10 mg/kg vs placebo | RR 1.33 [1.22, 1.45] | 4 studies · 2666 participants | High |
Change in HRQOL, on SF‐36 PCS score at 52 weeks Improvement in SF‐36 PCS score from baseline ( Belimumab 10 mg/kg vs placebo | MD 1.6 [0.3, 2.9] | 2 studies · 801 participants | Moderate Downgraded: imprecision |
Reduction of glucocorticoid dose by at least 50% Belimumab 10 mg/kg vs placebo | RR 1.59 [1.17, 2.15] | 2 studies · 537 participants | High |
Participants with one or more serious adverse events Belimumab 10 mg/kg vs placebo | RR 0.87 [0.68, 1.11] | 5 studies · 2890 participants | Low Downgraded: imprecision, inconsistency |
Participants with one or more serious infections Belimumab 10 mg/kg vs placebo | RR 1.01 [0.66, 1.54] | 4 studies · 2185 participants | Moderate Downgraded: imprecision |
Withdrawals due to adverse events Belimumab 10 mg/kg vs placebo | RR 0.82 [0.63, 1.07] | 5 studies · 2890 participants | Moderate Downgraded: imprecision |
Number of participants who died during the study Belimumab 10 mg/kg vs placebo | Peto OR 1.15 [0.41, 3.25] | 6 studies · 2917 participants | Low Downgraded: imprecision |