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What do systematic reviews say?

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Evidence found and GRADE certainty

80 questions · 80 findings · 48 reviews · Pregnancy and Childbirth

No studies found 4 · 5%GRADE not reported 5 · 6.3%Very low 11 · 13.8%Low 32 · 40%Moderate 14 · 17.5%High 14 · 17.5%

Vitamin E vs placebo, no placebo or other supplements

Preterm birth · pregnant women receiving vitamin E supplementation or control, living in areas where there is either inadequate dietary intake of vitamin…

Any vitamin E supplementation showed no clear difference in preterm birth (less than 37 weeks' gestation) compared with placebo, no placebo or other supplements (high certainty).

1 finding from 1 review

Cervical cerclage in combination with antibiotics and tocolytics vs cervical cerclage

Preterm birth less than 34 weeks' gestation

It is very uncertain whether cervical cerclage in combination with antibiotics and tocolytics changes preterm birth < 34 completed weeks of pregnancy compared with cervical cerclage alone (very low certainty).

1 finding from 1 review

Lower genital tract infection screening vs No screening

Preterm low birthweight (below or equal 2500 g) · pregnant women presenting for routine prenatal care

Lower genital tract infection screening probably leads to lower preterm low birthweight (below or equal 2500 g) compared with no screening (moderate certainty).

1 finding from 1 review

Lower genital tract infection screening vs No screening

Preterm very low birthweight (below or equal 1500 g) · pregnant women presenting for routine prenatal care

Lower genital tract infection screening probably leads to lower preterm very low birthweight (below or equal 1500 g) compared with no screening (moderate certainty).

1 finding from 1 review

Any supplements containing iron and folic acid vs same supplements without iron nor folic acid (no iron nor folic acid or placebo)

Preterm birth · pregnant women

(Infant outcomes) Any supplements containing iron and folic acid showed no clear difference in preterm birth (less than 37 weeks of gestation) (ALL) compared with same supplements without iron nor folic acid (no iron nor folic acid… (low certainty).

1 finding from 1 review

Any supplements containing iron vs same supplements without iron or no treatment/placebo (no iron or placebo)

Preterm birth · pregnant women

(Infant outcomes) Any supplements containing iron showed no clear difference in preterm birth (less than 37 weeks of gestation) (ALL) compared with same supplements without iron or no treatment/placebo (no iron or… (moderate certainty).

1 finding from 1 review

Setting of BP measurement: self‐measurement vs conventional clinic measurement

Preterm birth less than 34 weeks' gestation · pregnant women with chronic or gestational hypertension

Setting of BP measurement: self‐measurement showed no clear difference in preterm birth (birth before 34 completed weeks' gestation) compared with conventional clinic measurement (low certainty).

1 finding from 1 review

Group antenatal care vs individual antenatal care (adjusted data)

Gestational age (preterm birth < 37 weeks) · pregnant women accessing prenatal care

Group antenatal care showed no clear difference in preterm birth (gestational age at time of birth less than 37 weeks'… compared with individual antenatal care (adjusted data) (moderate certainty).

1 finding from 1 review

Intervention not reported

Very preterm birth (less than 34 weeks) ‐ assuming complete correlation between twins · women with multiple pregnancy

The intervention showed no clear difference in very preterm birth (less than 34 weeks) ‐ assuming complete… (low certainty).

1 finding from 1 review

Intervention not reported

Very preterm birth (less than 34 weeks) ‐ assuming complete correlation between twins/triplets · women with multiple pregnancy

The intervention showed no clear difference in very preterm birth (less than 34 weeks) ‐ assuming complete… (low certainty).

1 finding from 1 review

Intervention not reported

Pregnancy with serious adverse outcome (composite including maternal death, baby death, pre‐eclampsia, small‐for‐gestational age, preterm birth) ‐ only trials with individual participant data · pregnant women considered to be at risk of developing pre‐eclampsia

The intervention leads to lower pregnancy with serious adverse outcome (composite including maternal… (high certainty).

1 finding from 1 review