Cochrane · systematic review · CD012871
Cervical stitch (cerclage) in combination with other treatments for preventing spontaneous preterm birth in singleton pregnancies
Eleje, GU, Eke, AC, Ikechebelu, JI, et al. · Cochrane Database of Systematic Reviews · 2020 · Cochrane Library
Pregnancy and ChildbirthAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
6
current version
GRADE rated
4
No studies
2
Included studies
NR
No studies 2 · 33.3%Ungraded 0 · 0%Very low 4 · 66.7%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Cervical cerclage in combination with antibiotics and tocolytics versus cervical cerclage alone for preventing preterm birth in singleton pregnancies
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Serious neonatal morbidity (Reported in Miller 2014 as 'composite adverse outcome', which included the following neonatal morbidities: respiratory distress syndrome, necrotising enterocolitis, intraventricular haemorrhage, retinopathy of prematuri... Cervical cerclage in combination with antibiotics and tocolytics vs cervical cerclage alone | RR 0.62 [0.31, 1.24] | 1 study · 50 participants | Very low Downgraded: risk of bias, imprecision |
Perinatal loss: all ‐ including miscarriages and stillbirth (Note: data not available for neonatal death) Cervical cerclage in combination with antibiotics and tocolytics vs cervical cerclage alone | RR 0.46 [0.13, 1.64] | 1 study · 50 participants | Very low Downgraded: risk of bias, imprecision |
Baby discharged home healthy Cervical cerclage in combination with antibiotics and tocolytics vs cervical cerclage alone | no estimate extracted | NR | No studies |
Neonatal death before discharge Cervical cerclage in combination with antibiotics and tocolytics vs cervical cerclage alone | no estimate extracted | NR | No studies |
Stillbirth: intrauterine death at 24 or more weeks Cervical cerclage in combination with antibiotics and tocolytics vs cervical cerclage alone | no estimate extracted | 1 study · 50 participants | Very low Downgraded: risk of bias, imprecision |
Preterm birth < 34 completed weeks of pregnancy Cervical cerclage in combination with antibiotics and tocolytics vs cervical cerclage alone | RR 0.78 [0.44, 1.4] | 1 study · 50 participants | Very low Downgraded: risk of bias, imprecision |