Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

156 questions · 157 findings · 58 reviews · Headline outcomes only

No studies found 33 · 21%GRADE not reported 7 · 4.5%Very low 44 · 28%Low 40 · 25.5%Moderate 28 · 17.8%High 5 · 3.2%

Fibrinolytics vs placebo

Overall treatment failure, including mortality, thoracic surgery or referral for further fibrinolytic therapy · adult parapneumonic effusions and empyema

It is very uncertain whether fibrinolytics changes overall treatment failure, including mortality, thoracic surgery or… compared with placebo (very low certainty).

1 finding from 1 review

Summary of Findings Table ‐ Electrocoagulation in combination with allopurinol or with dimethyl sulphoxide vs control (vehicle solution of allopurinol by mouth)

All‐cause mortality at last · people with liver metastases

Summary of Findings Table ‐ Electrocoagulation in combination with… may leads to lower all‐cause mortality at last compared with control (vehicle solution of allopurinol by mouth) (low certainty).

1 finding from 1 review

Dopamine‐milrinone vs dopamine‐dobutamine

All‐cause short‐term mortality: at intensive care unit · adults with cardiogenic shock

It is very uncertain whether dopamine‐milrinone changes all‐cause short‐term mortality: at intensive care unit compared with dopamine‐dobutamine (very low certainty).

1 finding from 1 review

Glycopeptide (vancomycin or teicoplanin) plus aminoglycoside (gentamicin) vs beta‐lactam (cloxacillin) plus aminoglycoside (gentamicin)

All‐cause mortality during hospital stay and all‐cause mortality at 1 year · people with endocarditis due to Staphylococcus aureus in drug abusers

The review found no eligible studies for this question.

1 finding from 1 review

Retinoic acid post‐consolidation therapy vs no further treatment

Overall survival (reported as mortality) · high‐risk neuroblastoma patients treated with autologous HSCT

Retinoic acid postconsolidation therapy showed no clear difference in overall survival (reported as mortality) compared with no further treatment (low certainty).

1 finding from 1 review