Cochrane · systematic review · CD008771
Early versus late administration of amino acids in preterm infants receiving parenteral nutrition
Trivedi, A, Jatana, V, Sinn, JKH · Cochrane Database of Systematic Reviews · 2024 · Cochrane Library
NeonatalAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
4
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 3 · 42.9%Very low 0 · 0%Low 4 · 57.1%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Summary of findings table ‐ Early amino acids compared to Late amino acids for neonates born at <37 weeks of gestation
Population: neonates born at <37 weeks of gestation
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Growth during the first month of life Summary of findings table ‐ Early amino acids vs Late amino acids | no estimate extracted | 0 studies · 0 participants | Ungraded |
Growth during the first month of life Summary of findings table ‐ Early amino acids vs Late amino acids | no estimate extracted | 1 study · 21 participants | Low Downgraded: risk of bias, imprecision |
Growth during first month of life Summary of findings table ‐ Early amino acids vs Late amino acids | no estimate extracted | 2 studies · 87 participants | Low Downgraded: risk of bias, inconsistency |
Discharge weight Summary of findings table ‐ Early amino acids vs Late amino acids | no estimate extracted | 0 studies · 0 participants | Ungraded |
Neurodevelopmental outcome assessed by any standard tool Summary of findings table ‐ Early amino acids vs Late amino acids | OR 0.83 [0.21, 3.28] | 1 study · 111 participants | Low Downgraded: risk of bias |
All‐cause mortality at 28 days and before discharge from hospital Summary of findings table ‐ Early amino acids vs Late amino acids | no estimate extracted | 0 studies · 0 participants | Ungraded |
Nitrogen balance Summary of findings table ‐ Early amino acids vs Late amino acids | no estimate extracted | 4 studies · 93 participants | Low Downgraded: risk of bias |