Cochrane · systematic review · CD008864
Fibrinogen concentrate in bleeding patients
Wikkelsø, A, Lunde, J, Johansen, M, et al. · Cochrane Database of Systematic Reviews · 2013 · Cochrane Library
Emergency and Critical CareAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
5
current version
GRADE rated
5
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 5 · 100%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Fibrinogen concentrate versus any comparator for patients with bleeding
Population: bleeding patients or at risk of severe bleeding
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Mortality Fibrinogen concentrate vs any comparator | RR 0.28 [0.03, 2.33] | 2 studies · 81 participants | Very low Downgraded: risk of bias, imprecision |
Incidence of allogenic blood transfusion Proportion of participants transfused with RBC, FFP, PLT and/or cryo Fibrinogen concentrate vs any comparator | RR 0.47 [0.31, 0.72] | 5 studies · 207 participants | Very low Downgraded: risk of bias, imprecision |
Thrombotic episodes (arterial and venous graft occlusion, pulmonary embolus, deep venous thrombosis) Proportion with event Fibrinogen concentrate vs any comparator | RR 1.03 [0.27, 3.97] | 3 studies · 124 participants | Very low Downgraded: risk of bias, imprecision |
Intensive care unit (ICU) stay Duration of stay (hours) Fibrinogen concentrate vs any comparator | no estimate extracted | 3 studies · 112 participants | Very low Downgraded: risk of bias, imprecision |
Re‐operation due to persistent bleeding Events during admission Fibrinogen concentrate vs any comparator | RR 0.68 [0.01, 36.71] | 2 studies · 124 participants | Very low Downgraded: risk of bias, imprecision |