Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

25 questions · 25 findings · 18 reviews · Gynaecology and Fertility

No studies found 4 · 16%GRADE not reported 1 · 4%Very low 7 · 28%Low 6 · 24%Moderate 6 · 24%High 1 · 4%

Embryo culture with low oxygen concentration vs embryo culture with atmospheric oxygen concentration

Live birth rate · Patients with live birth rate

Embryo culture with low oxygen concentration probably leads to higher live birth rate compared with embryo culture with atmospheric oxygen concentration (moderate certainty).

1 finding from 1 review

Any anti‐adhesion therapy vs placebo or no treatment following operative hysteroscopy

Live birth · women treated by operative hysteroscopy for uterine pathology associated with subfertility or adverse pregnancy outcome

It is very uncertain whether any anti‐adhesion therapy changes live birth a compared with placebo or no treatment following operative hysteroscopy (very low certainty).

1 finding from 1 review

Any anti‐adhesion therapy vs anti‐adhesion therapy B following operative hysteroscopy

Live birth · women treated by operative hysteroscopy for uterine pathology

Any anti‐adhesion therapy A showed no clear difference in live birth a compared with anti‐adhesion therapy B following operative hysteroscopy (low certainty).

1 finding from 1 review

Repeated single embryo transfer (mixed policies) vs multiple embryo transfer

Cumulative live birth · transfer following in vitro fertilisation or intracytoplasmic sperm injection

Repeated single embryo transfer (mixed policies) showed no clear difference in cumulative live birth compared with multiple embryo transfer (low certainty).

1 finding from 1 review

Intervention not reported

Live birth/ongoing pregnancy ‐ low vs high dose protocol · subfertile women

It is very uncertain whether the intervention changes live birth/ongoing pregnancy ‐ low vs high dose protocol (very low certainty).

1 finding from 1 review

Day 3 vs Day 2 embryo transfer following IVF or ICSI

Live birth rate per woman · Women undergoing in vitro fertilisation or intracytoplasmic sperm injection

It is very uncertain whether day 3 changes live birth rate per woman compared with day 2 embryo transfer following IVF or ICSI (very low certainty).

1 finding from 1 review

Intervention not reported

Live birth or ongoing pregnancy Low dose vaginal vs high dose vaginal · subfertile women

The intervention showed no clear difference in live birth or ongoing pregnancy Low dose vaginal vs high dose vaginal (moderate certainty).

1 finding from 1 review

Intervention not reported

Live birth; type of antioxidant (natural conceptions and undergoing fertility treatments) ‐ Melatonin lower dose versus melatonin higher dose№ of participants: 140(2 RCTs) · women with subfertility

The intervention showed no clear difference in live birth; type of antioxidant (natural conceptions and undergoing… (low certainty).

1 finding from 1 review

Letrozole with or without adjuncts vs SERMs with or without adjuncts followed by timed intercourse

Live birth rate · infertile women with polycystic ovary syndrome

Letrozole with or without adjuncts leads to higher live birth rate compared with SERMs with or without adjuncts followed by timed intercourse (high certainty).

1 finding from 1 review

Hyaluronic acid‐selected sperm (HA‐ICSI) vs viscous medium containing HA (SpermSlow)

Live birth rate per woman · assisted reproduction

It is very uncertain whether hyaluronic acid‐selected sperm (HA‐ICSI) changes live birth per woman randomly assigned compared with viscous medium containing HA (SpermSlow) (very low certainty).

1 finding from 1 review