Cochrane · systematic review · CD008950
Low oxygen concentrations for embryo culture in assisted reproductive technologies
Bontekoe, S, Mantikou, E, van Wely, M, et al. · Cochrane Database of Systematic Reviews · 2012 · Cochrane Library
Gynaecology and FertilityAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
6
current version
GRADE rated
6
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 1 · 16.7%Low 2 · 33.3%Moderate 3 · 50%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Embryo culture with low oxygen concentration compared to embryo culture with atmospheric oxygen concentration for live birth rate
Population: Patients with live birth rate
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Live birth rate Embryo culture with low oxygen concentration vs embryo culture with atmospheric oxygen concentration | OR 1.39 [1.11, 1.76] | 3 studies · 1291 participants | Moderate Downgraded: risk of bias |
Embryo culture with low oxygen concentration compared to embryo culture with atmospheric oxygen concentration for ongoing pregnancy
Population: Patients with ongoing pregnancy
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Ongoing pregnancy rate Embryo culture with low oxygen concentration vs embryo culture with atmospheric oxygen concentration | OR 1.4 [1.11, 1.77] | 3 studies · 1291 participants | Moderate Downgraded: risk of bias |
Embryo culture with low oxygen concentration compared to embryo culture with atmospheric oxygen concentration for clinical pregnancy rate
Population: Patients with clinical pregnancy rate
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Clinical pregnancy rate Embryo culture with low oxygen concentration vs embryo culture with atmospheric oxygen concentration | OR 1.35 [1.08, 1.67] | 4 studies · 1382 participants | Moderate Downgraded: risk of bias |
Embryo culture with low oxygen concentration compared to embryo culture with atmospheric oxygen concentration for multiple pregnancy rate
Population: Patients with multiple pregnancy rate
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Multiple‐pregnancy rate Embryo culture with low oxygen concentration vs embryo culture with atmospheric oxygen concentration | OR 1.33 [0.91, 1.95] | 4 studies · 1382 participants | Low Downgraded: risk of bias |
Embryo culture with low oxygen concentration compared to embryo culture with atmospheric oxygen concentration for miscarriage rate
Population: patients with miscarriage rate
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Miscarriage rate Embryo culture with low oxygen concentration vs embryo culture with atmospheric oxygen concentration | OR 1.28 [0.86, 1.9] | 3 studies · 1291 participants | Low Downgraded: risk of bias |
Embryo culture with low oxygen concentration compared to embryo culture with atmospheric oxygen concentration for congenital abnormalities
Population: patients with congenital abnormalities
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Congenital abnormalities Embryo culture with low oxygen concentration vs embryo culture with atmospheric oxygen concentration | OR 0.2 [0.01, 4.09] | 1 study · 647 participants | Very low Downgraded: risk of bias |