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Evidence found and GRADE certainty

23 questions · 23 findings · 16 reviews · Pregnancy and Childbirth

No studies found 0 · 0%GRADE not reported 5 · 21.7%Very low 6 · 26.1%Low 10 · 43.5%Moderate 1 · 4.3%High 1 · 4.3%

Probiotics vs placebo

Hypertensive disorders of pregnancy: pre‐eclampsia · preventing gestational diabetes

Probiotics leads to higher hypertensive disorders of pregnancy (pre‐eclampsia) compared with placebo (high certainty).

1 finding from 1 review

Metformin vs insulin

Hypertensive disorders of pregnancy: pre‐eclampsia · women with type 2 diabetes

It is very uncertain whether maternal outcomes: oral anti‐diabetic agent (metformin) changes hypertensive disorders of pregnancy: pre‐eclampsia compared with insulin (very low certainty).

1 finding from 1 review

Summary of findings: Energy‐restricted diet vs no energy‐restricted diet (maternal outcomes)

Hypertensive disorders of pregnancy: pre‐eclampsia · pregnant women with GDM

Summary of findings: Energy‐restricted diet showed no clear difference in hypertensive disorders of pregnancy: pre‐eclampsia compared with no energy‐restricted diet (maternal outcomes) (low certainty).

1 finding from 1 review

Adverse event outcomes for dietary combined with physical activity interventions vs standard‐of‐care therapy

Hypertensive disorders of pregnancy: pre‐eclampsia · pregnant women, excluding women already diagnosed with GDM in this pregnancy and those with pre‐existing diabetes mellitus

Combined diet and exercise interventions showed no clear difference in hypertensive disorders of pregnancy (pre‐eclampsia) compared with standard care (mother) (low certainty).

1 finding from 1 review

Self‐monitoring vs intermittent glucose monitoring

Hypertensive disorders of pregnancy: pre‐eclampsia · women with gestational diabetes mellitus

It is very uncertain whether self‐monitoring changes hypertensive disorders of pregnancy: pre‐eclampsia compared with periodic glucose monitoring (very low certainty).

1 finding from 1 review

Lifestyle interventions vs control ‐ Maternal outcomes

Hypertensive disorders of pregnancy: pre‐eclampsia · women with gestational diabetes mellitus

Lifestyle interventions showed no clear difference in hypertensive disorders of pregnancy (pre‐eclampsia) compared with control ‐ Maternal outcomes (low certainty).

1 finding from 1 review

Primary care screening vs secondary care screening

Hypertensive disorders of pregnancy: pre‐eclampsia · pregnant women, excluding women already diagnosed with GDM in this pregnancy and those with pre‐existing diabetes mellitus

Primary care screening showed no clear difference in hypertensive disorders of pregnancy: pre‐eclampsia toxemia compared with secondary care screening (low certainty).

1 finding from 1 review

Reduced number of antenatal care visits/goal‐oriented vs standard antenatal care visits

Hypertensive disorders of pregnancy (including pre‐eclampsia) · Pregnant women at low risk of complications

Reduced number of antenatal care visits/goal‐oriented showed no clear difference in hypertensive disorders of pregnancy (including pre‐eclampsia) compared with standard antenatal care visits (low certainty).

1 finding from 1 review

Summary of findings: Low‐moderate GI diet vs moderate‐high GI diet (maternal outcomes)

Hypertensive disorders of pregnancy: severe hypertension or pre‐eclampsia · pregnant women with GDM

It is very uncertain whether summary of findings: Low‐moderate GI diet changes hypertensive disorders of pregnancy: severe hypertension or… compared with moderate‐high GI diet (maternal outcomes) (very low certainty).

1 finding from 1 review

Probiotics vs placebo

Hypertensive disorders (including pre‐eclampsia, pregnancy‐induced hypertension, eclampsia) · women with gestational diabetes mellitus

Probiotic showed no clear difference in hypertensive disorders (including pre‐eclampsia, pregnancy‐induced… compared with placebo (low certainty).

1 finding from 1 review

Intensity of glycaemic control for women with gestational diabetes mellitus ‐ strict glycaemic targets vs less‐tight glycaemic targets (maternal outcomes)

Hypertensive disorders of pregnancy · women with gestational diabetes mellitus

Intensity of glycaemic control for women with gestational diabetes… showed no clear difference in hypertensive disorders of pregnancy (including pre‐eclampsia,… compared with less‐tight glycaemic targets (maternal outcomes) (low certainty).

1 finding from 1 review

Continuous glucose monitoring system vs intermittent glucose monitoring

Hypertensive disorders of pregnancy · women with pre‐existing diabetes

Continuous glucose monitoring may leads to lower hypertensive disorders of pregnancy (including pre‐eclampsia,… compared with intermittent glucose monitoring (low certainty).

1 finding from 1 review