Cochrane · systematic review · CD012970
Probiotic treatment for women with gestational diabetes to improve maternal and infant health and well‐being
Okesene-Gafa, KAM, Moore, AE, Jordan, V, et al. · Cochrane Database of Systematic Reviews · 2020 · Cochrane Library
Pregnancy and ChildbirthAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
14
current version
GRADE rated
5
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 9 · 64.3%Very low 1 · 7.1%Low 4 · 28.6%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Probiotic compared to placebo for treating women with gestational diabetes for improving maternal and infant health and well‐being ‐ maternal outcomes
Population: pregnant women diagnosed with gestational diabetes
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Hypertensive disorders (including pre‐eclampsia, pregnancy‐induced hypertension, eclampsia) Probiotic vs placebo | RR 1.5 [0.64, 3.53] | 3 studies · 256 participants | Low Downgraded: imprecision |
Subsequent development of type 2 diabetes Probiotic vs placebo | no estimate extracted | 0 studies · 0 participants | Ungraded |
Mode of birth (caesarean) Probiotic vs placebo | RR 0.64 [0.3, 1.35] | 3 studies · 267 participants | Low Downgraded: imprecision, inconsistency, indirectness |
Induction of labour Probiotic vs placebo | RR 1.33 [0.74, 2.37] | 1 study · 127 participants | Very low Downgraded: imprecision, inconsistency, indirectness |
Perineal trauma Probiotic vs placebo | no estimate extracted | 0 studies · 0 participants | Ungraded |
Postnatal weight retention or return to pre‐pregnancy weight Probiotic vs placebo | no estimate extracted | 0 studies · 0 participants | Ungraded |
Postnatal depression Probiotic vs placebo | no estimate extracted | 0 studies · 0 participants | Ungraded |
Probiotic compared to placebo for treating women with gestational diabetes for improving maternal and infant health and well‐being‐ infant/child/adult outcome
Population: pregnant women diagnosed with gestational diabetes
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Perinatal (fetal and neonatal) mortality Probiotic vs placebo | no estimate extracted | 0 studies · 0 participants | Ungraded |
Large‐for‐gestational age > 90 centile Probiotic vs placebo | RR 0.73 [0.35, 1.52] | 2 studies · 174 participants | Low Downgraded: imprecision |
Composite serious neonatal outcomes (variously defined by trials, e.g. infant death, shoulder dystocia, bone fracture, or nerve palsy Probiotic vs placebo | no estimate extracted | 0 studies · 0 participants | Ungraded |
Neurosensory disability Probiotic vs placebo | no estimate extracted | 0 studies · 0 participants | Ungraded |
Neonatal hypoglycaemia requiring treatment (variously defined) Probiotic vs placebo | RR 0.85 [0.39, 1.84] | 3 studies · 177 participants | Low Downgraded: imprecision |
Adiposity (neonatal/child/child as an adult) Probiotic vs placebo | no estimate extracted | 0 studies · 0 participants | Ungraded |
Diabetes(type1 or type2) or impaired glucose tolerance (child/adult) Probiotic vs placebo | no estimate extracted | 0 studies · 0 participants | Ungraded |