Cochrane · systematic review · CD007724
Oral anti‐diabetic agents for women with established diabetes/impaired glucose tolerance or previous gestational diabetes planning pregnancy, or pregnant women with pre‐existing diabetes
Tieu, J, Coat, S, Hague, W, et al. · Cochrane Database of Systematic Reviews · 2017 · Cochrane Library
Pregnancy and ChildbirthAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
14
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 7 · 50%Very low 5 · 35.7%Low 2 · 14.3%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Maternal outcomes: oral anti‐diabetic agent (metformin) compared with insulin for women with established type 2 diabetes mellitus
Population: women with type 2 diabetes
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Hypertensive disorders of pregnancy: pre‐eclampsia Maternal outcomes: oral anti‐diabetic agent (metformin) vs insulin | RR 0.63 [0.33, 1.2] | 2 studies · 227 participants | Very low Downgraded: risk of bias |
Hypertensive disorders of pregnancy: pregnancy‐induced hypertension Maternal outcomes: oral anti‐diabetic agent (metformin) vs insulin | RR 0.58 [0.37, 0.91] | 1 study · 206 participants | Low Downgraded: risk of bias, imprecision |
Caesarean section Maternal outcomes: oral anti‐diabetic agent (metformin) vs insulin | RR 0.73 [0.61, 0.88] | 3 studies · 241 participants | Low Downgraded: risk of bias |
Induction of labour Maternal outcomes: oral anti‐diabetic agent (metformin) vs insulin | RR 1.42 [0.62, 3.28] | 2 studies · 35 participants | Very low Downgraded: risk of bias, imprecision |
Perineal trauma Maternal outcomes: oral anti‐diabetic agent (metformin) vs insulin | no estimate extracted | 0 studies · 0 participants | Ungraded |
Postnatal depression Maternal outcomes: oral anti‐diabetic agent (metformin) vs insulin | no estimate extracted | 0 studies · 0 participants | Ungraded |
Postnatal weight retention Maternal outcomes: oral anti‐diabetic agent (metformin) vs insulin | no estimate extracted | 0 studies · 0 participants | Ungraded |
Infant outcomes: oral anti‐diabetic agent (metformin) compared with insulin for women with established type 2 diabetes mellitus
Population: women with type 2 diabetes mellitus
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Large‐for‐gestational age Infant outcomes: oral anti‐diabetic agent (metformin) vs insulin | RR 1.12 [0.73, 1.72] | 1 study · 206 participants | Very low Downgraded: risk of bias |
Perinatal mortality Infant outcomes: oral anti‐diabetic agent (metformin) vs insulin | no estimate extracted | 2 studies · 220 participants | Very low Downgraded: risk of bias, imprecision |
Hypoglycaemia Infant outcomes: oral anti‐diabetic agent (metformin) vs insulin | RR 0.34 [0.18, 0.62] | 3 studies · 241 participants | Very low Downgraded: risk of bias, imprecision |
Neonatal mortality or morbidity composite Infant outcomes: oral anti‐diabetic agent (metformin) vs insulin | no estimate extracted | 0 studies · 0 participants | Ungraded |
Childhood/adulthood neurosensory disability Infant outcomes: oral anti‐diabetic agent (metformin) vs insulin | no estimate extracted | 0 studies · 0 participants | Ungraded |
Childhood/adulthood adiposity Infant outcomes: oral anti‐diabetic agent (metformin) vs insulin | no estimate extracted | 0 studies · 0 participants | Ungraded |
Childhood/adulthood diabetes Infant outcomes: oral anti‐diabetic agent (metformin) vs insulin | no estimate extracted | 0 studies · 0 participants | Ungraded |