Cochrane · systematic review · CD009951
Probiotics for preventing gestational diabetes
Davidson, SJ, Barrett, HL, Price, SA, et al. · Cochrane Database of Systematic Reviews · 2021 · Cochrane Library
Pregnancy and ChildbirthAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
14
current version
GRADE rated
9
No studies
5
Included studies
NR
No studies 5 · 35.7%Ungraded 0 · 0%Very low 0 · 0%Low 5 · 35.7%Moderate 2 · 14.3%High 2 · 14.3%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Probiotics compared to placebo for preventing gestational diabetes (maternal outcomes)
Population: preventing gestational diabetes
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Diagnosis of gestational diabetes mellitus Probiotics vs placebo | RR 0.8 [0.54, 1.2] | 6 studies · 1440 participants | Low Downgraded: imprecision, inconsistency |
Hypertensive disorders of pregnancy (pre‐eclampsia) Probiotics vs placebo | RR 1.85 [1.04, 3.29] | 4 studies · 955 participants | High |
Caesarean section Probiotics vs placebo | RR 1 [0.86, 1.17] | 6 studies · 1520 participants | High |
Perineal trauma Probiotics vs placebo | no estimate extracted | NR | No studies |
Weight gain during pregnancy Probiotics vs placebo | no estimate extracted | 4 studies · 853 participants | Moderate Downgraded: inconsistency |
Postnatal depression Probiotics vs placebo | no estimate extracted | NR | No studies |
Development of subsequent diabetes Probiotics vs placebo | no estimate extracted | NR | No studies |
Probiotics compared to placebo for preventing gestational diabetes (infant outcomes)
Population: preventing gestational diabetes
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Large‐for‐gestational age Probiotics vs placebo | RR 0.99 [0.72, 1.36] | 4 studies · 919 participants | Moderate Downgraded: imprecision |
Perinatal mortality (stillbirth and neonatal mortality) Probiotics vs placebo | RR 0.33 [0.01, 8.02] | 3 studies · 709 participants | Low Downgraded: imprecision |
Mortality or morbidity composite Probiotics vs placebo | RR 0.69 [0.36, 1.35] | 2 studies · 623 participants | Low Downgraded: imprecision |
Hypoglycaemia as defined by trialists Probiotics vs placebo | RR 1.15 [0.69, 1.92] | 2 studies · 586 participants | Low Downgraded: imprecision, inconsistency |
Adiposity Probiotics vs placebo | no estimate extracted | 2 studies · 320 participants | Low Downgraded: imprecision |
Diabetes Probiotics vs placebo | no estimate extracted | NR | No studies |
Neurodisability Probiotics vs placebo | no estimate extracted | NR | No studies |