Question · asked by 1 review
Metformin vs insulin: Hypertensive disorders of pregnancy: pre‐eclampsia
- Population
- women with type 2 diabetes
- Intervention
- Metformin
- Comparison
- insulin
- Outcome
- Hypertensive disorders of pregnancy: pre‐eclampsia
It is very uncertain whether maternal outcomes: oral anti‐diabetic agent (metformin) changes hypertensive disorders of pregnancy: pre‐eclampsia compared with insulin (very low certainty).
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Maternal outcomes: oral anti‐diabetic agent (metformin) vs insulin Hypertensive disorders of pregnancy: pre‐eclampsia · women with type 2 diabetes It is very uncertain whether maternal outcomes: oral anti‐diabetic agent (metformin) changes hypertensive disorders of pregnancy: pre‐eclampsia compared with insulin (very low certainty). Oral anti‐diabetic agents for women with established diabetes/impaired glucose tolerance or previous… (2017) · Cochrane Headline outcomes only | RR 0.63 [0.33, 1.2] | 2 studies · 227 participants | Very low |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Oral anti‐diabetic agents for women with established diabetes/impaired glucose tolerance or previous gestational diabetes planning… 2017 · Cochrane Headline outcomes only | Not reported | Not extracted | Not assessed |
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.