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Evidence found and GRADE certainty

392 questions · 793 findings · 64 reviews · Dental caries

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No studies found 3 · 0.4%GRADE not reported 753 · 95%Very low 31 · 3.9%Low 4 · 0.5%Moderate 2 · 0.3%High 0 · 0%

Maternal smoking during pregnancy vs No maternal smoking during pregnancy

Dental caries · children

Maternal smoking during pregnancy was associated with higher odds of dental caries in children (OR 1.78, 95% CI 1.55 to 2.05; ungraded).

14 findings from 2 reviews · compare the 2 reviews
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Prenatal vitamin D level ≤50 nmol/L vs Adequate prenatal vitamin D (sufficient maternal 25(OH)D)

Dental caries · Children aged 2 to 8 years

The review reported a lower odds ratio at maternal prenatal vitamin D ≤50 nmol/L than at ≤35 nmol/L, without a numeric value in the available sources.

1 finding from 1 review

Acidic bacillary pH on teeth vs Non-acidic bacillary pH

Dental caries · Primary school children in Ethiopia

Acidic bacillary pH on the teeth was associated with higher odds of dental caries (OR 2.42, 95% CI 1.494-3.335; ungraded).

1 finding from 1 review

Poor / no tooth brushing habit vs Good tooth brushing habit

Dental caries · Primary school children in Ethiopia

A poor tooth-cleaning habit was associated with higher odds of dental caries (OR 3.90, 95% CI 2.761-5.045; ungraded).

1 finding from 1 review

TT genotype vs TC+CC genotypes

Dental caries · Children (<18 years) with vs without dental caries

In the PCR-RFLP genotyping subgroup, TaqI(rs731236) recessive model: TT vs TC+CC showed no significant association with caries (OR 1.49); ungraded.

8 findings from 1 review
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TT+TC genotypes vs CC genotype

Dental caries · Children (<18 years) with vs without dental caries

In the Caucasian ethnicity subgroup, TaqI(rs731236) dominant model: TT+TC vs CC showed no significant association with caries (OR 0.84); ungraded.

8 findings from 1 review
Show 5 more findings

TT genotype vs TG+GG genotypes

Dental caries · Children (<18 years) with vs without dental caries

TaqI/BglI(rs739837) recessive model: TT vs TG+GG was not significantly associated with dental caries (OR 0.93); ungraded.

1 finding from 1 review

G allele vs A allele

Dental caries · Children (<18 years) with vs without dental caries

BsmI(rs1544410) allele distribution (G vs A) was not significantly associated with caries (OR 1.56; high heterogeneity); ungraded.

1 finding from 1 review

CC genotype vs CA+AA genotypes

Dental caries · Children (<18 years) with vs without dental caries

ApaI(rs7975232) recessive model: CC vs CA+AA was not significantly associated with dental caries (OR 0.87); ungraded.

1 finding from 1 review

T allele vs G allele

Dental caries · Children (<18 years) with vs without dental caries

TaqI/BglI(rs739837) allelic model: T vs G was not significantly associated with dental caries (OR 1.00); ungraded.

1 finding from 1 review

T allele vs C allele

Dental caries · Children (<18 years) with vs without dental caries

In the Permanent dentition subgroup, TaqI(rs731236) allelic model: T vs C showed no significant association with caries (OR 0.90); ungraded.

8 findings from 1 review
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Significant salivary microbial (Lactobacillus) load vs No/low significant microbial load

Dental caries · Primary school children in Ethiopia

A significant salivary microbial (Lactobacillus) load was associated with higher odds of dental caries (OR 3.82, 95% CI 3.439-4.192; ungraded).

1 finding from 1 review

C allele vs T allele

Dental caries · Children (<18 years) with vs without dental caries

FokI(rs10735810) C allele was significantly associated with higher caries risk vs T allele (pooled OR 1.33, 95% CI 1.03-1.71); ungraded.

1 finding from 1 review

CC+CT genotypes vs TT genotype

Dental caries · Children (<18 years) with vs without dental caries

CC+CT genotype at FokI(rs10735810) was associated with ~1.87-fold higher caries risk than TT (dominant model, OR 1.87); ungraded.

1 finding from 1 review

AA genotype vs AG+GG genotypes

Dental caries · Children (<18 years) with vs without dental caries

FokI(rs2228570) recessive model: AA vs AG+GG was not significantly associated with dental caries (OR 1.09); ungraded.

1 finding from 1 review

Prenatal vitamin D deficiency (low maternal 25(OH)D during pregnancy) vs Adequate prenatal vitamin D (sufficient maternal 25(OH)D)

Dental caries · Children aged 2 to 8 years

The review reported an OR of 1.32 when prenatal vitamin D was measured at 6 to 38 gestational weeks.

2 findings from 1 review

Absence of toothpaste use vs Toothpaste use

Dental caries · Primary school children in Ethiopia

Absence of toothpaste use was not significantly associated with dental caries (OR 1.42, 95% CI -1.278 to 4.109, p=0.3029; ungraded).

1 finding from 1 review

TT+CC (homozygous) genotypes vs TC (heterozygous) genotype

Dental caries · Children (<18 years) with vs without dental caries

In the Real-time quantitative PCR genotyping subgroup, TaqI(rs731236) over-dominant model: TT+CC vs TC showed a significant association with caries (OR 1.52); ungraded.

8 findings from 1 review
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Grade level 1-4 (first cycle) vs Grade level 5 or above

Dental caries · Primary school children in Ethiopia

Being in grade levels 1-4 was associated with higher odds of dental caries (OR 2.46, 95% CI 1.523-3.397; ungraded).

1 finding from 1 review

High intake of sweets vs Lower/less intake of sweets

Dental caries · Primary school children in Ethiopia

A high intake of sweets was associated with higher odds of dental caries (OR 2.71, 95% CI 1.968-3.451; ungraded).

1 finding from 1 review